Evaluation of Effects of Resveratrol Consumption on Serum Metabolic Profiles of Diabetes Type 1 Patients, by Using H Nuclear Magnetic Resonance Technique
Background & Objective: Diabetes mellitus type 1 is an autoimmune disease in which the B-cells of the pancreas are damaged, leading to insulin deficiency and finally hyperglycemia. The purpose of this study was to investigate the effect of resveratrol consumption on cellular metabolic pathways i...
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| Format: | Article |
| Language: | English |
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Fasa University of Medical Sciences
2020-11-01
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| Series: | Journal of Advanced Biomedical Sciences |
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| Online Access: | http://jabs.fums.ac.ir/article-1-2316-en.pdf |
| _version_ | 1797679566531067904 |
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| author | Seyed Hamidreza Hodaei Samad Akbarzadeh Mohammad Arjmand Ziba Akbari Najmeh Hajian azam amini Ali Movahed |
| author_facet | Seyed Hamidreza Hodaei Samad Akbarzadeh Mohammad Arjmand Ziba Akbari Najmeh Hajian azam amini Ali Movahed |
| author_sort | Seyed Hamidreza Hodaei |
| collection | DOAJ |
| description | Background & Objective: Diabetes mellitus type 1 is an autoimmune disease in which the B-cells of the pancreas are damaged, leading to insulin deficiency and finally hyperglycemia. The purpose of this study was to investigate the effect of resveratrol consumption on cellular metabolic pathways in type 1 diabetic patients using proton nuclear magnetic resonance spectroscopy.
Materials & Methods: Thirteen individuals with type 1 diabetes participated in this clinical trial designed as before and after exploratory investigation. All the participants received 500mg capsules of resveratrol twice daily for 60 days. Blood collection was done before resveratrol supplementation, after 30 days, and at the end of 60 days. The data were obtained at three different timings, compared with applying the HNMR spectroscopy. Spectra were processed, and PLS-DA analysis methods were applied to data. Outliers were taken, and the HMDB metabolites databank specified the metabolites and its pathways.
Results: The main variations identified in this investigation were as follows: short and long-chain fatty acid metabolism, the metabolic pathway of triacylglycerol, 1-propanol, and ethanoic acid, leading to an increase in butyraldehyde and 1-butanol metabolites.
Conclusion: The results of this research showed a reduction in palmitic acid biosynthesis. This finding suggests that resveratrol may cause significant changes in adipocyte metabolism by inducing adipogenesis and apoptosis in the adipocyte. It may also play a role in improving the production of insulin, leading to low blood glucose levels. |
| first_indexed | 2024-03-11T23:16:39Z |
| format | Article |
| id | doaj.art-8076192eb01740aaa71027b569596c98 |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:16:39Z |
| publishDate | 2020-11-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-8076192eb01740aaa71027b569596c982023-09-20T21:28:07ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232020-11-0110428472857Evaluation of Effects of Resveratrol Consumption on Serum Metabolic Profiles of Diabetes Type 1 Patients, by Using H Nuclear Magnetic Resonance TechniqueSeyed Hamidreza Hodaei0Samad Akbarzadeh1Mohammad Arjmand2Ziba Akbari3Najmeh Hajian4azam amini5Ali Movahed6 Department of Biochemistry, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran Department of Biochemistry, The Persian Gulf Infectious & Tropical Medicine Research CenterBushehr University of Medical Sciences, Bushehr, Iran Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran Department of Biochemistry, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran Bushehr University of Medical Sciences, Bushehr, Iran Department of Biochemistry, The Persian Gulf Infectious & Tropical Medicine Research CenterBushehr University of Medical Sciences, Bushehr, Iran Background & Objective: Diabetes mellitus type 1 is an autoimmune disease in which the B-cells of the pancreas are damaged, leading to insulin deficiency and finally hyperglycemia. The purpose of this study was to investigate the effect of resveratrol consumption on cellular metabolic pathways in type 1 diabetic patients using proton nuclear magnetic resonance spectroscopy. Materials & Methods: Thirteen individuals with type 1 diabetes participated in this clinical trial designed as before and after exploratory investigation. All the participants received 500mg capsules of resveratrol twice daily for 60 days. Blood collection was done before resveratrol supplementation, after 30 days, and at the end of 60 days. The data were obtained at three different timings, compared with applying the HNMR spectroscopy. Spectra were processed, and PLS-DA analysis methods were applied to data. Outliers were taken, and the HMDB metabolites databank specified the metabolites and its pathways. Results: The main variations identified in this investigation were as follows: short and long-chain fatty acid metabolism, the metabolic pathway of triacylglycerol, 1-propanol, and ethanoic acid, leading to an increase in butyraldehyde and 1-butanol metabolites. Conclusion: The results of this research showed a reduction in palmitic acid biosynthesis. This finding suggests that resveratrol may cause significant changes in adipocyte metabolism by inducing adipogenesis and apoptosis in the adipocyte. It may also play a role in improving the production of insulin, leading to low blood glucose levels.http://jabs.fums.ac.ir/article-1-2316-en.pdfresveratroltype 1 diabetesmetabolomics1h nmrpls-da |
| spellingShingle | Seyed Hamidreza Hodaei Samad Akbarzadeh Mohammad Arjmand Ziba Akbari Najmeh Hajian azam amini Ali Movahed Evaluation of Effects of Resveratrol Consumption on Serum Metabolic Profiles of Diabetes Type 1 Patients, by Using H Nuclear Magnetic Resonance Technique Journal of Advanced Biomedical Sciences resveratrol type 1 diabetes metabolomics 1h nmr pls-da |
| title | Evaluation of Effects of Resveratrol Consumption on Serum Metabolic Profiles of Diabetes Type 1 Patients, by Using H Nuclear Magnetic Resonance Technique |
| title_full | Evaluation of Effects of Resveratrol Consumption on Serum Metabolic Profiles of Diabetes Type 1 Patients, by Using H Nuclear Magnetic Resonance Technique |
| title_fullStr | Evaluation of Effects of Resveratrol Consumption on Serum Metabolic Profiles of Diabetes Type 1 Patients, by Using H Nuclear Magnetic Resonance Technique |
| title_full_unstemmed | Evaluation of Effects of Resveratrol Consumption on Serum Metabolic Profiles of Diabetes Type 1 Patients, by Using H Nuclear Magnetic Resonance Technique |
| title_short | Evaluation of Effects of Resveratrol Consumption on Serum Metabolic Profiles of Diabetes Type 1 Patients, by Using H Nuclear Magnetic Resonance Technique |
| title_sort | evaluation of effects of resveratrol consumption on serum metabolic profiles of diabetes type 1 patients by using h nuclear magnetic resonance technique |
| topic | resveratrol type 1 diabetes metabolomics 1h nmr pls-da |
| url | http://jabs.fums.ac.ir/article-1-2316-en.pdf |
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