Loop2 Size Modification Reveals Significant Impacts on the Potency of α-Conotoxin TxID

Loop2 Size Modification Reveals Significant Impacts on the Potency of α-Conotoxin TxID

α4/6-conotoxin TxID, which was identified from <i>Conus textile</i>, simultaneously blocks rat (r) α3β4 and rα6/α3β4 nicotinic acetylcholine receptors (nAChRs) with IC<sub>50</sub> values of 3.6 nM and 33.9 nM, respectively. In order to identify the effects of loop2 size on t...

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Bibliographic Details
Main Authors: Jianying Dong, Panpan Zhang, Junjie Xie, Ting Xie, Xiaopeng Zhu, Dongting Zhangsun, Jinpeng Yu, Sulan Luo
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Marine Drugs
Subjects:
α-conotoxin TxID
α3β4 nAChR
loop size modification
electrophysiology
CD spectra
Online Access:https://www.mdpi.com/1660-3397/21/5/286

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