Cardiac 18F-FDG Positron Emission Tomography: An Accurate Tool to Monitor In vivo Metabolic and Functional Alterations in Murine Myocardial Infarction
Cardiac monitoring after murine myocardial infarction, using serial non-invasive cardiac 18F-FDG positron emissions tomography (PET) represents a suitable and accurate tool for in vivo studies. Cardiac PET imaging enables tracking metabolic alterations, heart function parameters and provides correla...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.656742/full |
| _version_ | 1818607099952758784 |
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| author | Maximilian Fischer Maximilian Fischer Mathias J. Zacherl Ludwig Weckbach Ludwig Weckbach Lisa Paintmayer Tobias Weinberger Tobias Weinberger Konstantin Stark Konstantin Stark Steffen Massberg Steffen Massberg Peter Bartenstein Sebastian Lehner Sebastian Lehner Christian Schulz Christian Schulz Andrei Todica |
| author_facet | Maximilian Fischer Maximilian Fischer Mathias J. Zacherl Ludwig Weckbach Ludwig Weckbach Lisa Paintmayer Tobias Weinberger Tobias Weinberger Konstantin Stark Konstantin Stark Steffen Massberg Steffen Massberg Peter Bartenstein Sebastian Lehner Sebastian Lehner Christian Schulz Christian Schulz Andrei Todica |
| author_sort | Maximilian Fischer |
| collection | DOAJ |
| description | Cardiac monitoring after murine myocardial infarction, using serial non-invasive cardiac 18F-FDG positron emissions tomography (PET) represents a suitable and accurate tool for in vivo studies. Cardiac PET imaging enables tracking metabolic alterations, heart function parameters and provides correlations of the infarct size to histology. ECG-gated 18F-FDG PET scans using a dedicated small-animal PET scanner were performed in mice at baseline, 3, 14, and 30 days after myocardial infarct (MI) by permanent ligation of the left anterior descending (LAD) artery. The percentage of the injected dose per gram (%ID/g) in the heart, left ventricular metabolic volume (LVMV), myocardial defect, and left ventricular function parameters: end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and the ejection fraction (EF%) were estimated. PET assessment of the defect positively correlates with post-infarct histology at 3 and 30 days. Infarcted murine hearts show an immediate decrease in LVMV and an increase in %ID/g early after infarction, diminishing in the remodeling process. This study of serial cardiac PET scans provides insight for murine myocardial infarction models by novel infarct surrogate parameters. It depicts that serial PET imaging is a valid, accurate, and multimodal non-invasive assessment. |
| first_indexed | 2024-12-16T14:21:22Z |
| format | Article |
| id | doaj.art-807814f91a394d32a8f267086462ad21 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-16T14:21:22Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-807814f91a394d32a8f267086462ad212022-12-21T22:28:29ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-05-01810.3389/fcvm.2021.656742656742Cardiac 18F-FDG Positron Emission Tomography: An Accurate Tool to Monitor In vivo Metabolic and Functional Alterations in Murine Myocardial InfarctionMaximilian Fischer0Maximilian Fischer1Mathias J. Zacherl2Ludwig Weckbach3Ludwig Weckbach4Lisa Paintmayer5Tobias Weinberger6Tobias Weinberger7Konstantin Stark8Konstantin Stark9Steffen Massberg10Steffen Massberg11Peter Bartenstein12Sebastian Lehner13Sebastian Lehner14Christian Schulz15Christian Schulz16Andrei Todica17Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, GermanyDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, GermanyDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, Munich, GermanyMedizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, GermanyDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, GermanyDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, Munich, GermanyMedizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, GermanyDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, GermanyMedizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, GermanyDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, GermanyMedizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, GermanyDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, GermanyDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, Munich, GermanyDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, Munich, GermanyAmbulatory Healthcare Center Dr. Neumaier & Colleagues, Radiology, Nuclear Medicine, Radiation Therapy, Regensburg, GermanyMedizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, GermanyDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, GermanyDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, Munich, GermanyCardiac monitoring after murine myocardial infarction, using serial non-invasive cardiac 18F-FDG positron emissions tomography (PET) represents a suitable and accurate tool for in vivo studies. Cardiac PET imaging enables tracking metabolic alterations, heart function parameters and provides correlations of the infarct size to histology. ECG-gated 18F-FDG PET scans using a dedicated small-animal PET scanner were performed in mice at baseline, 3, 14, and 30 days after myocardial infarct (MI) by permanent ligation of the left anterior descending (LAD) artery. The percentage of the injected dose per gram (%ID/g) in the heart, left ventricular metabolic volume (LVMV), myocardial defect, and left ventricular function parameters: end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and the ejection fraction (EF%) were estimated. PET assessment of the defect positively correlates with post-infarct histology at 3 and 30 days. Infarcted murine hearts show an immediate decrease in LVMV and an increase in %ID/g early after infarction, diminishing in the remodeling process. This study of serial cardiac PET scans provides insight for murine myocardial infarction models by novel infarct surrogate parameters. It depicts that serial PET imaging is a valid, accurate, and multimodal non-invasive assessment.https://www.frontiersin.org/articles/10.3389/fcvm.2021.656742/fullcardiac positron emission tomography18F-FDGmyocardial infarctcardiac remodelingheart function |
| spellingShingle | Maximilian Fischer Maximilian Fischer Mathias J. Zacherl Ludwig Weckbach Ludwig Weckbach Lisa Paintmayer Tobias Weinberger Tobias Weinberger Konstantin Stark Konstantin Stark Steffen Massberg Steffen Massberg Peter Bartenstein Sebastian Lehner Sebastian Lehner Christian Schulz Christian Schulz Andrei Todica Cardiac 18F-FDG Positron Emission Tomography: An Accurate Tool to Monitor In vivo Metabolic and Functional Alterations in Murine Myocardial Infarction Frontiers in Cardiovascular Medicine cardiac positron emission tomography 18F-FDG myocardial infarct cardiac remodeling heart function |
| title | Cardiac 18F-FDG Positron Emission Tomography: An Accurate Tool to Monitor In vivo Metabolic and Functional Alterations in Murine Myocardial Infarction |
| title_full | Cardiac 18F-FDG Positron Emission Tomography: An Accurate Tool to Monitor In vivo Metabolic and Functional Alterations in Murine Myocardial Infarction |
| title_fullStr | Cardiac 18F-FDG Positron Emission Tomography: An Accurate Tool to Monitor In vivo Metabolic and Functional Alterations in Murine Myocardial Infarction |
| title_full_unstemmed | Cardiac 18F-FDG Positron Emission Tomography: An Accurate Tool to Monitor In vivo Metabolic and Functional Alterations in Murine Myocardial Infarction |
| title_short | Cardiac 18F-FDG Positron Emission Tomography: An Accurate Tool to Monitor In vivo Metabolic and Functional Alterations in Murine Myocardial Infarction |
| title_sort | cardiac 18f fdg positron emission tomography an accurate tool to monitor in vivo metabolic and functional alterations in murine myocardial infarction |
| topic | cardiac positron emission tomography 18F-FDG myocardial infarct cardiac remodeling heart function |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.656742/full |
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