Enhanced vitamin K expenditure as a major contributor to vitamin K deficiency in COVID-19
Objectives: Vitamin K deficiency consistently associates with worse clinical outcome in COVID-19 patients. However, whether this is due to increased expenditure during inflammation or poor vitamin K status prior to infection remained unknown. Methods: Dp-ucMGP levels of 128 individuals were measured...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222005690 |
| _version_ | 1828163052934004736 |
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| author | Margot P.J. Visser Jona Walk Cees Vermeer Simona Bílková Rob Janssen Otto Mayer |
| author_facet | Margot P.J. Visser Jona Walk Cees Vermeer Simona Bílková Rob Janssen Otto Mayer |
| author_sort | Margot P.J. Visser |
| collection | DOAJ |
| description | Objectives: Vitamin K deficiency consistently associates with worse clinical outcome in COVID-19 patients. However, whether this is due to increased expenditure during inflammation or poor vitamin K status prior to infection remained unknown. Methods: Dp-ucMGP levels of 128 individuals were measured for the post-MONICA study and were compared to SARS-CoV-2 PCR testing results. Results: Dp-ucMGP levels prior to COVID-19 infection were not significantly different comparing PCR-negative, PCR-positive and not hospitalized, and PCR-positive and hospitalized patients. Conclusion: In this study, we demonstrate normal vitamin K status prior to infection in SARS-CoV-2 positive patients, supporting the theory of increased utilisation during disease. |
| first_indexed | 2024-04-12T01:04:39Z |
| format | Article |
| id | doaj.art-807bc5d26e314b9497197f9fb4199771 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-12T01:04:39Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-807bc5d26e314b9497197f9fb41997712022-12-22T03:54:20ZengElsevierInternational Journal of Infectious Diseases1201-97122022-12-01125275277Enhanced vitamin K expenditure as a major contributor to vitamin K deficiency in COVID-19Margot P.J. Visser0Jona Walk1Cees Vermeer2Simona Bílková3Rob Janssen4Otto Mayer5Department of Pulmonary Medicine, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands; Corresponding author: Margot Visser, Department of Pulmonary Medicine, Canisius-Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ Nijmegen, The NetherlandsDepartment of Internal Medicine, Canisius-Wilhelmina Hospital, Nijmegen, The NetherlandsDepartment of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The NetherlandsDepartment of Internal Medicine, University Hospital of Pilsen, Pilsen, Czech RepublicDepartment of Pulmonary Medicine, Canisius-Wilhelmina Hospital, Nijmegen, The NetherlandsDepartment of Internal Medicine, University Hospital of Pilsen, Pilsen, Czech RepublicObjectives: Vitamin K deficiency consistently associates with worse clinical outcome in COVID-19 patients. However, whether this is due to increased expenditure during inflammation or poor vitamin K status prior to infection remained unknown. Methods: Dp-ucMGP levels of 128 individuals were measured for the post-MONICA study and were compared to SARS-CoV-2 PCR testing results. Results: Dp-ucMGP levels prior to COVID-19 infection were not significantly different comparing PCR-negative, PCR-positive and not hospitalized, and PCR-positive and hospitalized patients. Conclusion: In this study, we demonstrate normal vitamin K status prior to infection in SARS-CoV-2 positive patients, supporting the theory of increased utilisation during disease.http://www.sciencedirect.com/science/article/pii/S1201971222005690COVID-19Matrix Gla ProteinDp-ucMGPElastic fibersVitamin K |
| spellingShingle | Margot P.J. Visser Jona Walk Cees Vermeer Simona Bílková Rob Janssen Otto Mayer Enhanced vitamin K expenditure as a major contributor to vitamin K deficiency in COVID-19 International Journal of Infectious Diseases COVID-19 Matrix Gla Protein Dp-ucMGP Elastic fibers Vitamin K |
| title | Enhanced vitamin K expenditure as a major contributor to vitamin K deficiency in COVID-19 |
| title_full | Enhanced vitamin K expenditure as a major contributor to vitamin K deficiency in COVID-19 |
| title_fullStr | Enhanced vitamin K expenditure as a major contributor to vitamin K deficiency in COVID-19 |
| title_full_unstemmed | Enhanced vitamin K expenditure as a major contributor to vitamin K deficiency in COVID-19 |
| title_short | Enhanced vitamin K expenditure as a major contributor to vitamin K deficiency in COVID-19 |
| title_sort | enhanced vitamin k expenditure as a major contributor to vitamin k deficiency in covid 19 |
| topic | COVID-19 Matrix Gla Protein Dp-ucMGP Elastic fibers Vitamin K |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222005690 |
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