Galanin ameliorates liver inflammation and fibrosis in mice by activating AMPK/ACC signaling and modifying macrophage inflammatory phenotype

Galanin ameliorates liver inflammation and fibrosis in mice by activating AMPK/ACC signaling and modifying macrophage inflammatory phenotype

Background and aimsGalanin is a naturally occurring peptide that plays a critical role in regulating inflammation and energy metabolism, with expression in the liver. The exact involvement of galanin in non-alcoholic fatty liver disease and related fibrosis remains controversial.MethodsThe effects o...

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Bibliographic Details
Main Authors: Lingnan He, Chao Huang, Hui Wang, Naibin Yang, Jianbin Zhang, Leiming Xu, Ting Gu, Zhenghong Li, Yuanwen Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
galanin
non-alcoholic steatohepatitis
liver fibrosis
macrophage
AMPK
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161676/full

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