Aging and Progression of Beta-Amyloid Pathology in Alzheimer’s Disease Correlates with Microglial Heme-Oxygenase-1 Overexpression

Aging and Progression of Beta-Amyloid Pathology in Alzheimer’s Disease Correlates with Microglial Heme-Oxygenase-1 Overexpression

Neuroinflammation and oxidative stress are being recognized as characteristic hallmarks in many neurodegenerative diseases, especially those that portray proteinopathy, such as Alzheimer’s disease (AD). Heme-oxygenase 1 (HO-1) is an inducible enzyme with antioxidant and anti-inflammatory properties,...

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Bibliographic Details
Main Authors: Cristina Fernández-Mendívil, Miguel A. Arreola, Lindsay A. Hohsfield, Kim N. Green, Manuela G. Lopez
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Antioxidants
Subjects:
Heme oxygenase-1
microglia
Alzheimer’s disease
beta-amyloid plaques
Online Access:https://www.mdpi.com/2076-3921/9/7/644

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