Mesenchymal stem cells overexpressing IL-35: a novel immunosuppressive strategy and therapeutic target for inducing transplant tolerance

Mesenchymal stem cells overexpressing IL-35: a novel immunosuppressive strategy and therapeutic target for inducing transplant tolerance

Abstract Inducing donor-specific immunological tolerance, which avoids the complications of long-term immunosuppression, is an important goal in organ transplantation. Interleukin-35 (IL-35), a cytokine identified in 2007, is mainly secreted by regulatory T cells (Tregs) and is essential for Tregs t...

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Bibliographic Details
Main Authors: Hao Guo, Baozhu Li, Wei Wang, Na Zhao, Haopeng Gao
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Stem Cell Research & Therapy
Subjects:
Interleukin-35
MSCs
Exosomes
Gene modification
Transplant tolerance
Online Access:http://link.springer.com/article/10.1186/s13287-018-0988-9

Internet

http://link.springer.com/article/10.1186/s13287-018-0988-9

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