Antibacterial activity of cellulose/chitosan green composite for wound healing
Cellulosic antibacterial fibers have great importance in the manufacturing of healthcare products. In this research work, antibacterial hemp and bamboo fibers were selected for manufacturing two green composite for wound healing. The chitosan was selected to get gel formation and behave as carrier i...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mehran University of Engineering and Technology
2023-10-01
|
| Series: | Mehran University Research Journal of Engineering and Technology |
| Online Access: | https://publications.muet.edu.pk/index.php/muetrj/article/view/2915 |
| _version_ | 1827798077044424704 |
|---|---|
| author | Mazhar Sanbhal Zulfiqar Solangi Sanam Irum Memon Noor Sanbhal Tahreem khanzada khadija Qureshi Wang Wei |
| author_facet | Mazhar Sanbhal Zulfiqar Solangi Sanam Irum Memon Noor Sanbhal Tahreem khanzada khadija Qureshi Wang Wei |
| author_sort | Mazhar Sanbhal |
| collection | DOAJ |
| description | Cellulosic antibacterial fibers have great importance in the manufacturing of healthcare products. In this research work, antibacterial hemp and bamboo fibers were selected for manufacturing two green composite for wound healing. The chitosan was selected to get gel formation and behave as carrier in the manufacturing of cellulosic/chitosan green composite. Moreover, a water-soluble levofloxacin was included to give a release of antibacterial properties. The hemp and bamboo fibers were cleaned and fiber-to-fiber separation was done with a manual comber machine. The chitosan was solubilized using acetic acid and stirred for 12 hours to get a completely clear and viscous gel. Afterward, powder ground hemp and bamboo fibers were separately poured into two separate beakers. Two different types of composites (hemp/chitosan) and Bamboo/chitosan were transferred into petri dishes and dried in the oven at 400C for 24 hours. The samples were loaded with a levofloxacin antimicrobial agent. Both composites (hemp/chitosan, and bamboo/chitosan) were characterized for surface morphology, structural changes and antimicrobial testing against gram-positive and gram-negative bacteria. It was analyzed that without levofloxacin both cellulose/chitosan composites resisted bacteria growth and did not show inhibition zone, but samples loaded with levofloxacin displayed good antibacterial activity and showed excellent zone of inhibition against gram-positive and gram-negative bacteria. Futhermore, FTIR evidenced that there was no formation of cross linking composites, but composites were held together due to chitosan and fibers gel formation. |
| first_indexed | 2024-03-11T19:31:55Z |
| format | Article |
| id | doaj.art-8081e62615af40ce9bb71c144667161d |
| institution | Directory Open Access Journal |
| issn | 0254-7821 2413-7219 |
| language | English |
| last_indexed | 2024-03-11T19:31:55Z |
| publishDate | 2023-10-01 |
| publisher | Mehran University of Engineering and Technology |
| record_format | Article |
| series | Mehran University Research Journal of Engineering and Technology |
| spelling | doaj.art-8081e62615af40ce9bb71c144667161d2023-10-06T13:16:52ZengMehran University of Engineering and TechnologyMehran University Research Journal of Engineering and Technology0254-78212413-72192023-10-01424849210.22581/muet1982.2304.29152915Antibacterial activity of cellulose/chitosan green composite for wound healingMazhar Sanbhal0Zulfiqar Solangi1Sanam Irum Memon2Noor Sanbhal3Tahreem khanzada4khadija Qureshi5Wang Wei6College of Chemistry, Chemical Engineering, Donghua University Shanghai 201620 China | Department of Chemical Engineering, Mehran University of Engineering and Technology Jamshoro 76062 Sindh PakistanDepartment of Chemical Engineering, Mehran University of Engineering and Technology Jamshoro 76062 Sindh PakistanDepartment of Textile Engineering, Mehran University of Engineering and Technology Jamshoro 76062 Sindh PakistanDepartment of Textile Engineering, Mehran University of Engineering and Technology Jamshoro 76062 Sindh PakistanDepartment of Textile Engineering, Mehran University of Engineering and Technology Jamshoro 76062 Sindh PakistanDepartment of Chemical Engineering, Mehran University of Engineering and Technology Jamshoro 76062 Sindh PakistanCollege of Chemistry, Chemical Engineering, Donghua University Shanghai 201620 ChinaCellulosic antibacterial fibers have great importance in the manufacturing of healthcare products. In this research work, antibacterial hemp and bamboo fibers were selected for manufacturing two green composite for wound healing. The chitosan was selected to get gel formation and behave as carrier in the manufacturing of cellulosic/chitosan green composite. Moreover, a water-soluble levofloxacin was included to give a release of antibacterial properties. The hemp and bamboo fibers were cleaned and fiber-to-fiber separation was done with a manual comber machine. The chitosan was solubilized using acetic acid and stirred for 12 hours to get a completely clear and viscous gel. Afterward, powder ground hemp and bamboo fibers were separately poured into two separate beakers. Two different types of composites (hemp/chitosan) and Bamboo/chitosan were transferred into petri dishes and dried in the oven at 400C for 24 hours. The samples were loaded with a levofloxacin antimicrobial agent. Both composites (hemp/chitosan, and bamboo/chitosan) were characterized for surface morphology, structural changes and antimicrobial testing against gram-positive and gram-negative bacteria. It was analyzed that without levofloxacin both cellulose/chitosan composites resisted bacteria growth and did not show inhibition zone, but samples loaded with levofloxacin displayed good antibacterial activity and showed excellent zone of inhibition against gram-positive and gram-negative bacteria. Futhermore, FTIR evidenced that there was no formation of cross linking composites, but composites were held together due to chitosan and fibers gel formation.https://publications.muet.edu.pk/index.php/muetrj/article/view/2915 |
| spellingShingle | Mazhar Sanbhal Zulfiqar Solangi Sanam Irum Memon Noor Sanbhal Tahreem khanzada khadija Qureshi Wang Wei Antibacterial activity of cellulose/chitosan green composite for wound healing Mehran University Research Journal of Engineering and Technology |
| title | Antibacterial activity of cellulose/chitosan green composite for wound healing |
| title_full | Antibacterial activity of cellulose/chitosan green composite for wound healing |
| title_fullStr | Antibacterial activity of cellulose/chitosan green composite for wound healing |
| title_full_unstemmed | Antibacterial activity of cellulose/chitosan green composite for wound healing |
| title_short | Antibacterial activity of cellulose/chitosan green composite for wound healing |
| title_sort | antibacterial activity of cellulose chitosan green composite for wound healing |
| url | https://publications.muet.edu.pk/index.php/muetrj/article/view/2915 |
| work_keys_str_mv | AT mazharsanbhal antibacterialactivityofcellulosechitosangreencompositeforwoundhealing AT zulfiqarsolangi antibacterialactivityofcellulosechitosangreencompositeforwoundhealing AT sanamirummemon antibacterialactivityofcellulosechitosangreencompositeforwoundhealing AT noorsanbhal antibacterialactivityofcellulosechitosangreencompositeforwoundhealing AT tahreemkhanzada antibacterialactivityofcellulosechitosangreencompositeforwoundhealing AT khadijaqureshi antibacterialactivityofcellulosechitosangreencompositeforwoundhealing AT wangwei antibacterialactivityofcellulosechitosangreencompositeforwoundhealing |