Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed mice
Obesity threatens human health worldwide, and mounting findings have found that gut microbiota (GM) changes induced by diet intervention influence its development. This study aims to investigate the anti-obesity effects and GM changes of propionylated high-amylose maize starch (PS) in C57BL/6J mice...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623000476 |
| _version_ | 1811155496518811648 |
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| author | Zhuqing Xie Minghua Yao Josué L. Castro-Mejía Ming Ma Yuyan Zhu Xiong Fu Qiang Huang Bin Zhang |
| author_facet | Zhuqing Xie Minghua Yao Josué L. Castro-Mejía Ming Ma Yuyan Zhu Xiong Fu Qiang Huang Bin Zhang |
| author_sort | Zhuqing Xie |
| collection | DOAJ |
| description | Obesity threatens human health worldwide, and mounting findings have found that gut microbiota (GM) changes induced by diet intervention influence its development. This study aims to investigate the anti-obesity effects and GM changes of propionylated high-amylose maize starch (PS) in C57BL/6J mice fed with high-fat diet (HFD). In our results, PS decreased the body weight of HFD-fed mice after 8 weeks and regulated the glucose stability and insulin resistance. High-amylose maize starch (HAMS) and PS regulated the serum lipid levels and inflammatory response. Moreover, PS yielded more propionate relative to HAMS, proving that introduced propionyl groups could be released in the colon. 16S rRNA results showed that PS altered GM with the increase of bacteria (S24-7 and Ruminococcus) and decrease of harmful genera, which is linked to the anti-obesity effect. Our results provide a reference for the design of functional dietary fibers inducing high propionate production and GM modulation. |
| first_indexed | 2024-04-10T04:35:18Z |
| format | Article |
| id | doaj.art-8082a0dc9b3d4944a7ede96580a6c18c |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-10T04:35:18Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-8082a0dc9b3d4944a7ede96580a6c18c2023-03-10T04:34:32ZengElsevierJournal of Functional Foods1756-46462023-03-01102105447Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed miceZhuqing Xie0Minghua Yao1Josué L. Castro-Mejía2Ming Ma3Yuyan Zhu4Xiong Fu5Qiang Huang6Bin Zhang7School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, China; Department of Food Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, DenmarkShanghai Jiaotong University School of Medicine, Shanghai General Hospital, Shanghai 200080, China; Corresponding authors at: School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, China (B.Z.).Department of Food Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, DenmarkShanghai Institute of Ceramics, Chinese Academy of Sciences, State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai 200050, ChinaDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, ChinaSchool of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, ChinaSchool of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, ChinaSchool of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, China; Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health, South China University of Technology, Guangzhou 510640, China; Corresponding authors at: School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, China (B.Z.).Obesity threatens human health worldwide, and mounting findings have found that gut microbiota (GM) changes induced by diet intervention influence its development. This study aims to investigate the anti-obesity effects and GM changes of propionylated high-amylose maize starch (PS) in C57BL/6J mice fed with high-fat diet (HFD). In our results, PS decreased the body weight of HFD-fed mice after 8 weeks and regulated the glucose stability and insulin resistance. High-amylose maize starch (HAMS) and PS regulated the serum lipid levels and inflammatory response. Moreover, PS yielded more propionate relative to HAMS, proving that introduced propionyl groups could be released in the colon. 16S rRNA results showed that PS altered GM with the increase of bacteria (S24-7 and Ruminococcus) and decrease of harmful genera, which is linked to the anti-obesity effect. Our results provide a reference for the design of functional dietary fibers inducing high propionate production and GM modulation.http://www.sciencedirect.com/science/article/pii/S1756464623000476Propionylated high-amylose maize starchHigh-fat dietPropionateGut microbiota |
| spellingShingle | Zhuqing Xie Minghua Yao Josué L. Castro-Mejía Ming Ma Yuyan Zhu Xiong Fu Qiang Huang Bin Zhang Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed mice Journal of Functional Foods Propionylated high-amylose maize starch High-fat diet Propionate Gut microbiota |
| title | Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed mice |
| title_full | Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed mice |
| title_fullStr | Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed mice |
| title_full_unstemmed | Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed mice |
| title_short | Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed mice |
| title_sort | propionylated high amylose maize starch alleviates obesity by modulating gut microbiota in high fat diet fed mice |
| topic | Propionylated high-amylose maize starch High-fat diet Propionate Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623000476 |
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