| Summary: | Herein, we investigated the surface characterization and biocompatibility of a denture-lining material containing <i>Cnidium officinale</i> extracts and its antifungal efficacy against <i>Candida albicans</i>. To achieve this, a denture-lining material containing various concentrations of <i>C. officinale</i> extract and a control group without <i>C. officinale</i> extract were prepared. The surface characterization and biocompatibility of the samples were investigated. In addition, the antifungal efficacy of the samples on <i>C. albicans</i> was investigated using spectrophotometric growth and a LIVE/DEAD assay. The results revealed that there was no significant difference between the biocompatibility of the experimental and control groups (<i>p</i> > 0.05). However, there was a significant difference between the antifungal efficiency of the denture material on <i>C. albicans</i> and that of the control group (<i>p</i> < 0.05), which was confirmed by the LIVE/DEAD assay. These results indicate the promising potential of the <i>C. officinale</i> extract-containing denture-lining material as an antifungal dental material.
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