The Interaction between Nidovirales and Autophagy Components
Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numerous pathogens, including viruse...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-07-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/9/7/182 |
| _version_ | 1819070258300846080 |
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| author | Yingying Cong Pauline Verlhac Fulvio Reggiori |
| author_facet | Yingying Cong Pauline Verlhac Fulvio Reggiori |
| author_sort | Yingying Cong |
| collection | DOAJ |
| description | Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numerous pathogens, including viruses, usurp autophagy in order to promote their propagation. Nidovirales are an order of enveloped viruses with large single-stranded positive RNA genomes. Four virus families (Arterividae, Coronaviridae, Mesoniviridae, and Roniviridae) are part of this order, which comprises several human and animal pathogens of medical and veterinary importance. In host cells, Nidovirales induce membrane rearrangements including autophagosome formation. The relevance and putative mechanism of autophagy usurpation, however, remain largely elusive. Here, we review the current knowledge about the possible interplay between Nidovirales and autophagy. |
| first_indexed | 2024-12-21T17:03:05Z |
| format | Article |
| id | doaj.art-80843a0c22c7487c88bf7b788e5524c2 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-21T17:03:05Z |
| publishDate | 2017-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-80843a0c22c7487c88bf7b788e5524c22022-12-21T18:56:35ZengMDPI AGViruses1999-49152017-07-019718210.3390/v9070182v9070182The Interaction between Nidovirales and Autophagy ComponentsYingying Cong0Pauline Verlhac1Fulvio Reggiori2Department of Cell Biology, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, 9713 AV Groningen, The NetherlandsDepartment of Cell Biology, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, 9713 AV Groningen, The NetherlandsDepartment of Cell Biology, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, 9713 AV Groningen, The NetherlandsAutophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numerous pathogens, including viruses, usurp autophagy in order to promote their propagation. Nidovirales are an order of enveloped viruses with large single-stranded positive RNA genomes. Four virus families (Arterividae, Coronaviridae, Mesoniviridae, and Roniviridae) are part of this order, which comprises several human and animal pathogens of medical and veterinary importance. In host cells, Nidovirales induce membrane rearrangements including autophagosome formation. The relevance and putative mechanism of autophagy usurpation, however, remain largely elusive. Here, we review the current knowledge about the possible interplay between Nidovirales and autophagy.https://www.mdpi.com/1999-4915/9/7/182coronavirusarterivirusmesonivirusronivirusautophagosomeautophagic fluxinfectionreplicationegression |
| spellingShingle | Yingying Cong Pauline Verlhac Fulvio Reggiori The Interaction between Nidovirales and Autophagy Components Viruses coronavirus arterivirus mesonivirus ronivirus autophagosome autophagic flux infection replication egression |
| title | The Interaction between Nidovirales and Autophagy Components |
| title_full | The Interaction between Nidovirales and Autophagy Components |
| title_fullStr | The Interaction between Nidovirales and Autophagy Components |
| title_full_unstemmed | The Interaction between Nidovirales and Autophagy Components |
| title_short | The Interaction between Nidovirales and Autophagy Components |
| title_sort | interaction between nidovirales and autophagy components |
| topic | coronavirus arterivirus mesonivirus ronivirus autophagosome autophagic flux infection replication egression |
| url | https://www.mdpi.com/1999-4915/9/7/182 |
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