Quantitative target engagement of RIPK1 in human whole blood via the cellular thermal shift assay for potential pre-clinical and clinical applications

Quantitative target engagement of RIPK1 in human whole blood via the cellular thermal shift assay for potential pre-clinical and clinical applications

The cellular thermal shift assay (CETSA®) is a target engagement method widely used for preclinical characterization of small molecule compounds. CETSA® has been used for semi-quantitative readouts in whole blood with PBMC isolation, and quantitative, plate-based readouts using cell lines. However,...

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Bibliographic Details
Main Authors: Shitalben Patel, Marie Karlsson, Joseph T. Klahn, Frank Gambino, Jr., Helena Costa, Kathleen A. McGuire, Christina K. Baumgartner, Jon Williams, Sarah Sandoz, James E. Kath
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:SLAS Discovery
Subjects:
CETSA
Target engagement
Blood
RIPK1
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555223000977

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http://www.sciencedirect.com/science/article/pii/S2472555223000977

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