People with genetic kidney diseases on kidney replacement therapy have different clinical outcomes compared to people with other kidney diseases
Abstract Despite increasing awareness of genetic kidney disease prevalence, there is limited population-level information about long term outcomes of people with genetic kidney disease receiving kidney replacement therapy. This analysis included people who commenced kidney replacement therapy betwee...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-57273-x |
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| author | Helen Y. Han Venkat Vangaveti Matthew Jose Monica Suet Ying Ng Andrew John Mallett |
| author_facet | Helen Y. Han Venkat Vangaveti Matthew Jose Monica Suet Ying Ng Andrew John Mallett |
| author_sort | Helen Y. Han |
| collection | DOAJ |
| description | Abstract Despite increasing awareness of genetic kidney disease prevalence, there is limited population-level information about long term outcomes of people with genetic kidney disease receiving kidney replacement therapy. This analysis included people who commenced kidney replacement therapy between 1989 and 2020 as recorded in the Australian and New Zealand Dialysis and Transplant registry. Genetic kidney diseases were subclassified as majority and minority monogenic. Non-genetic kidney diseases were included as the comparator group. Primary outcome measures were 10-year mortality and 10-year graft failure. Cox proportional hazard regression were used to calculate unadjusted and adjusted hazard ratios (AHRs) for primary outcomes. There were 59,231 people in the dialysis subgroup and 21,860 people in the transplant subgroup. People on dialysis with genetic kidney diseases had reduced 10-year mortality risk (majority monogenic AHR: 0.70, 95% CI 0.66–0.76; minority monogenic AHR 0.86, 95% CI 0.80–0.92). This reduced 10-year mortality risk continued after kidney transplantation (majority monogenic AHR: 0.82, 95% CI 0.71–0.93; minority monogenic AHR 0.80, 95% CI 0.68–0.95). Majority monogenic genetic kidney diseases were associated with reduced 10-year graft failure compared to minority monogenic genetic kidney diseases and other kidney diseases (majority monogenic AHR 0.69, 95% CI 0.59–0.79). This binational registry analysis identified that people with genetic kidney disease have different mortality and graft failure risks compared to people with other kidney diseases. |
| first_indexed | 2024-04-24T19:57:10Z |
| format | Article |
| id | doaj.art-80861e7e980c43bbaa989ad1de0f2707 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T19:57:10Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-80861e7e980c43bbaa989ad1de0f27072024-03-24T12:18:10ZengNature PortfolioScientific Reports2045-23222024-03-0114111010.1038/s41598-024-57273-xPeople with genetic kidney diseases on kidney replacement therapy have different clinical outcomes compared to people with other kidney diseasesHelen Y. Han0Venkat Vangaveti1Matthew Jose2Monica Suet Ying Ng3Andrew John Mallett4School of Medicine, The University of TasmaniaCollege of Medicine and Dentistry, James Cook UniversityHobart Clinical School, University of TasmaniaKidney Health Service, Royal Brisbane and Women’s HospitalCollege of Medicine and Dentistry, James Cook UniversityAbstract Despite increasing awareness of genetic kidney disease prevalence, there is limited population-level information about long term outcomes of people with genetic kidney disease receiving kidney replacement therapy. This analysis included people who commenced kidney replacement therapy between 1989 and 2020 as recorded in the Australian and New Zealand Dialysis and Transplant registry. Genetic kidney diseases were subclassified as majority and minority monogenic. Non-genetic kidney diseases were included as the comparator group. Primary outcome measures were 10-year mortality and 10-year graft failure. Cox proportional hazard regression were used to calculate unadjusted and adjusted hazard ratios (AHRs) for primary outcomes. There were 59,231 people in the dialysis subgroup and 21,860 people in the transplant subgroup. People on dialysis with genetic kidney diseases had reduced 10-year mortality risk (majority monogenic AHR: 0.70, 95% CI 0.66–0.76; minority monogenic AHR 0.86, 95% CI 0.80–0.92). This reduced 10-year mortality risk continued after kidney transplantation (majority monogenic AHR: 0.82, 95% CI 0.71–0.93; minority monogenic AHR 0.80, 95% CI 0.68–0.95). Majority monogenic genetic kidney diseases were associated with reduced 10-year graft failure compared to minority monogenic genetic kidney diseases and other kidney diseases (majority monogenic AHR 0.69, 95% CI 0.59–0.79). This binational registry analysis identified that people with genetic kidney disease have different mortality and graft failure risks compared to people with other kidney diseases.https://doi.org/10.1038/s41598-024-57273-xRegistryGenetic kidney diseaseMortalityKidney failureKidney transplantDialysis |
| spellingShingle | Helen Y. Han Venkat Vangaveti Matthew Jose Monica Suet Ying Ng Andrew John Mallett People with genetic kidney diseases on kidney replacement therapy have different clinical outcomes compared to people with other kidney diseases Scientific Reports Registry Genetic kidney disease Mortality Kidney failure Kidney transplant Dialysis |
| title | People with genetic kidney diseases on kidney replacement therapy have different clinical outcomes compared to people with other kidney diseases |
| title_full | People with genetic kidney diseases on kidney replacement therapy have different clinical outcomes compared to people with other kidney diseases |
| title_fullStr | People with genetic kidney diseases on kidney replacement therapy have different clinical outcomes compared to people with other kidney diseases |
| title_full_unstemmed | People with genetic kidney diseases on kidney replacement therapy have different clinical outcomes compared to people with other kidney diseases |
| title_short | People with genetic kidney diseases on kidney replacement therapy have different clinical outcomes compared to people with other kidney diseases |
| title_sort | people with genetic kidney diseases on kidney replacement therapy have different clinical outcomes compared to people with other kidney diseases |
| topic | Registry Genetic kidney disease Mortality Kidney failure Kidney transplant Dialysis |
| url | https://doi.org/10.1038/s41598-024-57273-x |
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