Adult stem cell deficits drive Slc29a3 disorders in mice
Mutations in equilibrative nucleoside transporter 3 (ENT3), encoded by SLC29A3, cause a spectrum of human genetic disorders. Here, the authors show altered haematopoietic stem cell and mesenchymal stem cell fates in ENT3-deficient mice, due to misregulation of the AMPK-mTOR-ULK axis.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10925-3 |
| _version_ | 1818857676671549440 |
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| author | Sreenath Nair Anne M. Strohecker Avinash K. Persaud Bhawana Bissa Shanmugam Muruganandan Craig McElroy Rakesh Pathak Michelle Williams Radhika Raj Amal Kaddoumi Alex Sparreboom Aaron M. Beedle Rajgopal Govindarajan |
| author_facet | Sreenath Nair Anne M. Strohecker Avinash K. Persaud Bhawana Bissa Shanmugam Muruganandan Craig McElroy Rakesh Pathak Michelle Williams Radhika Raj Amal Kaddoumi Alex Sparreboom Aaron M. Beedle Rajgopal Govindarajan |
| author_sort | Sreenath Nair |
| collection | DOAJ |
| description | Mutations in equilibrative nucleoside transporter 3 (ENT3), encoded by SLC29A3, cause a spectrum of human genetic disorders. Here, the authors show altered haematopoietic stem cell and mesenchymal stem cell fates in ENT3-deficient mice, due to misregulation of the AMPK-mTOR-ULK axis. |
| first_indexed | 2024-12-19T08:44:11Z |
| format | Article |
| id | doaj.art-808693518ee945b095baa8826e112354 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:44:11Z |
| publishDate | 2019-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-808693518ee945b095baa8826e1123542022-12-21T20:28:51ZengNature PortfolioNature Communications2041-17232019-07-0110112010.1038/s41467-019-10925-3Adult stem cell deficits drive Slc29a3 disorders in miceSreenath Nair0Anne M. Strohecker1Avinash K. Persaud2Bhawana Bissa3Shanmugam Muruganandan4Craig McElroy5Rakesh Pathak6Michelle Williams7Radhika Raj8Amal Kaddoumi9Alex Sparreboom10Aaron M. Beedle11Rajgopal Govindarajan12Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, Ohio State UniversityDepartment of Cancer Biology and Genetics, College of Medicine, Ohio State UniversityDivision of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, Ohio State UniversityDivision of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, Ohio State UniversityDivision of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, Ohio State UniversityDivision of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, Ohio State UniversityDivision of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, Ohio State UniversityDepartment of Radiology, Ohio State UniversityDivision of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, Ohio State UniversityDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn UniversityDivision of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, Ohio State UniversityDepartment of Pharmaceutical Sciences, SUNY Binghamton UniversityDivision of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, Ohio State UniversityMutations in equilibrative nucleoside transporter 3 (ENT3), encoded by SLC29A3, cause a spectrum of human genetic disorders. Here, the authors show altered haematopoietic stem cell and mesenchymal stem cell fates in ENT3-deficient mice, due to misregulation of the AMPK-mTOR-ULK axis.https://doi.org/10.1038/s41467-019-10925-3 |
| spellingShingle | Sreenath Nair Anne M. Strohecker Avinash K. Persaud Bhawana Bissa Shanmugam Muruganandan Craig McElroy Rakesh Pathak Michelle Williams Radhika Raj Amal Kaddoumi Alex Sparreboom Aaron M. Beedle Rajgopal Govindarajan Adult stem cell deficits drive Slc29a3 disorders in mice Nature Communications |
| title | Adult stem cell deficits drive Slc29a3 disorders in mice |
| title_full | Adult stem cell deficits drive Slc29a3 disorders in mice |
| title_fullStr | Adult stem cell deficits drive Slc29a3 disorders in mice |
| title_full_unstemmed | Adult stem cell deficits drive Slc29a3 disorders in mice |
| title_short | Adult stem cell deficits drive Slc29a3 disorders in mice |
| title_sort | adult stem cell deficits drive slc29a3 disorders in mice |
| url | https://doi.org/10.1038/s41467-019-10925-3 |
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