Risedronate-loaded aerogel scaffolds for bone regeneration
AbstractSugarcane bagasse-derived nanofibrillated cellulose (NFC), a type of cellulose with a fibrous structure, is potentially used in the pharmaceutical field. Regeneration of this cellulose using a green process offers a more accessible and less ordered cellulose II structure (amorphous cellulose...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Drug Delivery |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10717544.2022.2152135 |
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| author | Nahla El-Wakil Rabab Kamel Azza A. Mahmoud Alain Dufresne Ragab E. Abouzeid Mahmoud T. Abo El-Fadl Amr Maged |
| author_facet | Nahla El-Wakil Rabab Kamel Azza A. Mahmoud Alain Dufresne Ragab E. Abouzeid Mahmoud T. Abo El-Fadl Amr Maged |
| author_sort | Nahla El-Wakil |
| collection | DOAJ |
| description | AbstractSugarcane bagasse-derived nanofibrillated cellulose (NFC), a type of cellulose with a fibrous structure, is potentially used in the pharmaceutical field. Regeneration of this cellulose using a green process offers a more accessible and less ordered cellulose II structure (amorphous cellulose; AmC). Furthermore, the preparation of cross-linked cellulose (NFC/AmC) provides a dual advantage by building a structural block that could exhibit distinct mechanical properties. 3D aerogel scaffolds loaded with risedronate were prepared in our study using NFC or cross-linked cellulose (NFC/AmC), then combined with different concentrations of chitosan. Results proved that the aerogel scaffolds composed of NFC and chitosan had significantly improved the mechanical properties and retarded drug release compared to all other fabricated aerogel scaffolds. The aerogel scaffolds containing the highest concentration of chitosan (SC-T3) attained the highest compressive strength and mean release time values (415 ± 41.80 kPa and 2.61 ± 0.23 h, respectively). Scanning electron microscope images proved the uniform highly porous microstructure of SC-T3 with interconnectedness. All the tested medicated as well as unmedicated aerogel scaffolds had the ability to regenerate bone as assessed using the MG-63 cell line, with the former attaining a higher effect than the latter. However, SC-T3 aerogel scaffolds possessed a lower regenerative effect than those composed of NFC only. This study highlights the promising approach of the use of biopolymers derived from agro-wastes for tissue engineering. |
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| format | Article |
| id | doaj.art-80880e13b8da4a0686fc787105fa99e8 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-04-24T23:34:02Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-80880e13b8da4a0686fc787105fa99e82024-03-15T14:22:17ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642023-12-01301516310.1080/10717544.2022.2152135Risedronate-loaded aerogel scaffolds for bone regenerationNahla El-Wakil0Rabab Kamel1Azza A. Mahmoud2Alain Dufresne3Ragab E. Abouzeid4Mahmoud T. Abo El-Fadl5Amr Maged6Cellulose and Paper Department, National Research Centre, Giza, EgyptPharmaceutical Technology Department, National Research Centre, Giza, EgyptPharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Future University in Egypt, New Cairo, EgyptCNRS, Grenoble INP, LGP2, Université Grenoble Alpes, Grenoble, FranceCellulose and Paper Department, National Research Centre, Giza, EgyptBiochemistry Department, Biotechnology Research Institute, National Research Centre, Giza, EgyptPharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Future University in Egypt, New Cairo, EgyptAbstractSugarcane bagasse-derived nanofibrillated cellulose (NFC), a type of cellulose with a fibrous structure, is potentially used in the pharmaceutical field. Regeneration of this cellulose using a green process offers a more accessible and less ordered cellulose II structure (amorphous cellulose; AmC). Furthermore, the preparation of cross-linked cellulose (NFC/AmC) provides a dual advantage by building a structural block that could exhibit distinct mechanical properties. 3D aerogel scaffolds loaded with risedronate were prepared in our study using NFC or cross-linked cellulose (NFC/AmC), then combined with different concentrations of chitosan. Results proved that the aerogel scaffolds composed of NFC and chitosan had significantly improved the mechanical properties and retarded drug release compared to all other fabricated aerogel scaffolds. The aerogel scaffolds containing the highest concentration of chitosan (SC-T3) attained the highest compressive strength and mean release time values (415 ± 41.80 kPa and 2.61 ± 0.23 h, respectively). Scanning electron microscope images proved the uniform highly porous microstructure of SC-T3 with interconnectedness. All the tested medicated as well as unmedicated aerogel scaffolds had the ability to regenerate bone as assessed using the MG-63 cell line, with the former attaining a higher effect than the latter. However, SC-T3 aerogel scaffolds possessed a lower regenerative effect than those composed of NFC only. This study highlights the promising approach of the use of biopolymers derived from agro-wastes for tissue engineering.https://www.tandfonline.com/doi/10.1080/10717544.2022.2152135Risedronate sodiumcellulosecrosslinkingchitosanaerogelimplants |
| spellingShingle | Nahla El-Wakil Rabab Kamel Azza A. Mahmoud Alain Dufresne Ragab E. Abouzeid Mahmoud T. Abo El-Fadl Amr Maged Risedronate-loaded aerogel scaffolds for bone regeneration Drug Delivery Risedronate sodium cellulose crosslinking chitosan aerogel implants |
| title | Risedronate-loaded aerogel scaffolds for bone regeneration |
| title_full | Risedronate-loaded aerogel scaffolds for bone regeneration |
| title_fullStr | Risedronate-loaded aerogel scaffolds for bone regeneration |
| title_full_unstemmed | Risedronate-loaded aerogel scaffolds for bone regeneration |
| title_short | Risedronate-loaded aerogel scaffolds for bone regeneration |
| title_sort | risedronate loaded aerogel scaffolds for bone regeneration |
| topic | Risedronate sodium cellulose crosslinking chitosan aerogel implants |
| url | https://www.tandfonline.com/doi/10.1080/10717544.2022.2152135 |
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