Maternal Supplementation of Vitamin E or Its Combination with Hydroxytyrosol Increases the Gut Health and Short Chain Fatty Acids of Piglets at Weaning
An adequate intestinal environment before weaning may contribute to diarrhea predisposition and piglet development. This study evaluates how the dietary supplementation of vitamin E (VE) (100 mg/kg), hydroxytyrosol (HXT) (1.5 mg/kg) or the combined administration (VE + HXT) given to Iberian sows fro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/9/1761 |
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| author | Hernan D. Laviano Gerardo Gómez Rosa Escudero Yolanda Nuñez Juan M. García-Casco María Muñoz Ana Heras-Molina Clemente López-Bote Antonio González-Bulnes Cristina Óvilo Ana I. Rey |
| author_facet | Hernan D. Laviano Gerardo Gómez Rosa Escudero Yolanda Nuñez Juan M. García-Casco María Muñoz Ana Heras-Molina Clemente López-Bote Antonio González-Bulnes Cristina Óvilo Ana I. Rey |
| author_sort | Hernan D. Laviano |
| collection | DOAJ |
| description | An adequate intestinal environment before weaning may contribute to diarrhea predisposition and piglet development. This study evaluates how the dietary supplementation of vitamin E (VE) (100 mg/kg), hydroxytyrosol (HXT) (1.5 mg/kg) or the combined administration (VE + HXT) given to Iberian sows from gestation affects the piglet’s faecal characteristics, short chain fatty acids (SCFAs), fatty acid profile or intestinal morphology as indicators of gut health; and quantify the contribution of the oxidative status and colostrum/milk composition to the piglet’s SCFAs content and intestinal health. Dietary VE increased isobutyric acid (iC4), butyric acid (C4), isovaleric acid (iC5), and ∑SCFAs, whereas HXT increased iC4 and tended to decrease ∑SCFAs of faeces. Piglets from HXT-supplemented sows also tended to have higher faecal C20:4n-6/C20:2 ratio C22:6 proportion and showed lower <i>occludin</i> gene expression in the duodenum. The combination of both antioxidants had a positive effect on iC4 and iC5 levels. Correlation analyses and regression equations indicate that faecal SCFAs were related to oxidative status (mainly plasma VE) and colostrum and milk composition (mainly C20:2, C20:3, C20:4 n-6). This study would confirm the superiority of VE over HXT supplementation to improve intestinal homeostasis, gut health, and, consequently piglet growth. |
| first_indexed | 2024-03-10T23:05:34Z |
| format | Article |
| id | doaj.art-80886c96cecf4d4d80b2d2c749bffc9b |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T23:05:34Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-80886c96cecf4d4d80b2d2c749bffc9b2023-11-19T09:20:03ZengMDPI AGAntioxidants2076-39212023-09-01129176110.3390/antiox12091761Maternal Supplementation of Vitamin E or Its Combination with Hydroxytyrosol Increases the Gut Health and Short Chain Fatty Acids of Piglets at WeaningHernan D. Laviano0Gerardo Gómez1Rosa Escudero2Yolanda Nuñez3Juan M. García-Casco4María Muñoz5Ana Heras-Molina6Clemente López-Bote7Antonio González-Bulnes8Cristina Óvilo9Ana I. Rey10Departamento Producción Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro s/n., 28040 Madrid, SpainInstituto Regional de Investigación y Desarrollo Agroalimentario y Forestal de Castilla-La Mancha (IRIAF), 13700 Tomelloso, SpainDepartamento Producción Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro s/n., 28040 Madrid, SpainDepartamento de Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, INIA, CSIC, Ctra Coruña km 7.5, 28040 Madrid, SpainDepartamento de Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, INIA, CSIC, Ctra Coruña km 7.5, 28040 Madrid, SpainDepartamento de Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, INIA, CSIC, Ctra Coruña km 7.5, 28040 Madrid, SpainDepartamento Producción Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro s/n., 28040 Madrid, SpainDepartamento Producción Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro s/n., 28040 Madrid, SpainDepartamento de Producción y Sanidad Animal, Facultad de Veterinaria, Universidad Cardenal Herrera—CEU, CEU Universities, C/Tirant lo Blanc, 7, Alfara del Patriarca, 46115 Valencia, SpainDepartamento de Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, INIA, CSIC, Ctra Coruña km 7.5, 28040 Madrid, SpainDepartamento Producción Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro s/n., 28040 Madrid, SpainAn adequate intestinal environment before weaning may contribute to diarrhea predisposition and piglet development. This study evaluates how the dietary supplementation of vitamin E (VE) (100 mg/kg), hydroxytyrosol (HXT) (1.5 mg/kg) or the combined administration (VE + HXT) given to Iberian sows from gestation affects the piglet’s faecal characteristics, short chain fatty acids (SCFAs), fatty acid profile or intestinal morphology as indicators of gut health; and quantify the contribution of the oxidative status and colostrum/milk composition to the piglet’s SCFAs content and intestinal health. Dietary VE increased isobutyric acid (iC4), butyric acid (C4), isovaleric acid (iC5), and ∑SCFAs, whereas HXT increased iC4 and tended to decrease ∑SCFAs of faeces. Piglets from HXT-supplemented sows also tended to have higher faecal C20:4n-6/C20:2 ratio C22:6 proportion and showed lower <i>occludin</i> gene expression in the duodenum. The combination of both antioxidants had a positive effect on iC4 and iC5 levels. Correlation analyses and regression equations indicate that faecal SCFAs were related to oxidative status (mainly plasma VE) and colostrum and milk composition (mainly C20:2, C20:3, C20:4 n-6). This study would confirm the superiority of VE over HXT supplementation to improve intestinal homeostasis, gut health, and, consequently piglet growth.https://www.mdpi.com/2076-3921/12/9/1761vitamin Ehydroxytyrosolpiglet’s SCFAsgut healthsow dietantioxidants |
| spellingShingle | Hernan D. Laviano Gerardo Gómez Rosa Escudero Yolanda Nuñez Juan M. García-Casco María Muñoz Ana Heras-Molina Clemente López-Bote Antonio González-Bulnes Cristina Óvilo Ana I. Rey Maternal Supplementation of Vitamin E or Its Combination with Hydroxytyrosol Increases the Gut Health and Short Chain Fatty Acids of Piglets at Weaning Antioxidants vitamin E hydroxytyrosol piglet’s SCFAs gut health sow diet antioxidants |
| title | Maternal Supplementation of Vitamin E or Its Combination with Hydroxytyrosol Increases the Gut Health and Short Chain Fatty Acids of Piglets at Weaning |
| title_full | Maternal Supplementation of Vitamin E or Its Combination with Hydroxytyrosol Increases the Gut Health and Short Chain Fatty Acids of Piglets at Weaning |
| title_fullStr | Maternal Supplementation of Vitamin E or Its Combination with Hydroxytyrosol Increases the Gut Health and Short Chain Fatty Acids of Piglets at Weaning |
| title_full_unstemmed | Maternal Supplementation of Vitamin E or Its Combination with Hydroxytyrosol Increases the Gut Health and Short Chain Fatty Acids of Piglets at Weaning |
| title_short | Maternal Supplementation of Vitamin E or Its Combination with Hydroxytyrosol Increases the Gut Health and Short Chain Fatty Acids of Piglets at Weaning |
| title_sort | maternal supplementation of vitamin e or its combination with hydroxytyrosol increases the gut health and short chain fatty acids of piglets at weaning |
| topic | vitamin E hydroxytyrosol piglet’s SCFAs gut health sow diet antioxidants |
| url | https://www.mdpi.com/2076-3921/12/9/1761 |
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