RNAi-Mediated Knockdown of Cottontail Rabbit Papillomavirus Oncogenes Using Low-Toxicity Lipopolyplexes as a Paradigm to Treat Papillomavirus-Associated Cancers

RNAi-Mediated Knockdown of Cottontail Rabbit Papillomavirus Oncogenes Using Low-Toxicity Lipopolyplexes as a Paradigm to Treat Papillomavirus-Associated Cancers

The cottontail rabbit papillomavirus (CRPV)-associated VX2 carcinoma of the New Zealand White rabbit serves as a model system for human papillomavirus (HPV)-associated head and neck squamous cell carcinomas (HNSCCs). The aim of this study was to evaluate the tumor-inhibiting effect of RNAi-mediated...

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Bibliographic Details
Main Authors: Uzma Ali, Michael Bette, Ghazala Ambreen, Shashank R. Pinnapireddy, Imran Tariq, André Marquardt, Boris A. Stuck, Udo Bakowsky, Robert Mandic
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Pharmaceutics
Subjects:
head and neck cancer
HNSCC
VX2 carcinoma
papillomavirus
CRPV
E6
Online Access:https://www.mdpi.com/1999-4923/15/10/2379

Internet

https://www.mdpi.com/1999-4923/15/10/2379

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