Asiatic Acid Prevents Oxidative Stress and Apoptosis by Inhibiting the Translocation of α-Synuclein Into Mitochondria

Asiatic Acid Prevents Oxidative Stress and Apoptosis by Inhibiting the Translocation of α-Synuclein Into Mitochondria

The association of α-synuclein (α-syn) with mitochondria occurs through interaction with mitochondrial complex I. Defects in this protein have been linked to the pathogenesis of Parkinson disease (PD). Overexpression of α-synuclein in cells has been suggested to cause elevations in mitochondrial oxi...

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Bibliographic Details
Main Authors: Hongqun Ding, Yuyun Xiong, Jing Sun, Chen Chen, Jing Gao, Huaxi Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Neuroscience
Subjects:
α-synuclein
mitochondrion
apoptosis
asiatic acid
Parkinson disease
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00431/full

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