Characterization of a spontaneous mouse model of mild, accelerated aging via ECM degradation in emphysematous lungs

Characterization of a spontaneous mouse model of mild, accelerated aging via ECM degradation in emphysematous lungs

Abstract Emphysema limits airflow and causes irreversible progression of chronic obstructive pulmonary disease (COPD). Strain differences must be considered when selecting mouse models of COPD, owing to disease complexity. We previously reported that a novel C57BL/6JJcl substrain, the Mayumi-Emphyse...

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Main Authors: Ryosuke Tanino, Yukari Tsubata, Takamasa Hotta, Tamio Okimoto, Yoshihiro Amano, Mayumi Takechi, Tetsuya Tanaka, Tomomi Akita, Mamiko Nagase, Chikamasa Yamashita, Koichiro Wada, Takeshi Isobe
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-37638-4

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https://doi.org/10.1038/s41598-023-37638-4

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