An Approach for a Synthetic CTL Vaccine Design against Zika Flavivirus Using Class I and Class II Epitopes Identified by Computer Modeling

An Approach for a Synthetic CTL Vaccine Design against Zika Flavivirus Using Class I and Class II Epitopes Identified by Computer Modeling

The threat posed by severe congenital abnormalities related to Zika virus (ZKV) infection during pregnancy has turned development of a ZKV vaccine into an emergency. Recent work suggests that the cytotoxic T lymphocyte (CTL) response to infection is an important defense mechanism in response to ZKV....

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Bibliographic Details
Main Authors: Edecio Cunha-Neto, Daniela S. Rosa, Paul E. Harris, Tim Olson, Alex Morrow, Serban Ciotlos, Charles V. Herst, Reid Martin Rubsamen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
Zika vaccine
epitope
CTL vaccine
protein folding
dengue
flavivirus
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00640/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00640/full

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