A case of Magnusiomyces capitatus isolated during monitoring in an antimicrobial diagnostic stewardship context.
Magnusiomyces capitatus (M. capitatus) is an emerging opportunistic yeast in the Mediterranean region typically isolated from immunocompromised patients, usually affected by blood malignancies. We reported a rare case of M. capitatus infection, isolated from a drainage fluid in a patient affected by...
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Elsevier
2024-01-01
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| Series: | IDCases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250924000350 |
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| author | Francesco Foglia Giuseppe Greco Carla Zannella Annalisa Chianese Annalisa Ambrosino Alessandra Conzo Giovanni Conzo Anna De Filippis Emiliana Finamore Ludovico Docimo Massimiliano Galdiero |
| author_facet | Francesco Foglia Giuseppe Greco Carla Zannella Annalisa Chianese Annalisa Ambrosino Alessandra Conzo Giovanni Conzo Anna De Filippis Emiliana Finamore Ludovico Docimo Massimiliano Galdiero |
| author_sort | Francesco Foglia |
| collection | DOAJ |
| description | Magnusiomyces capitatus (M. capitatus) is an emerging opportunistic yeast in the Mediterranean region typically isolated from immunocompromised patients, usually affected by blood malignancies. We reported a rare case of M. capitatus infection, isolated from a drainage fluid in a patient affected by lung cancer recovered in the University Hospital of Campania “Luigi Vanvitelli”, Naples, Italy. The isolate was identified by phenotypic methods, i.e., Gram and Lactophenol cotton blue (LCB) staining, and matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) analysis. We identified M. capitatus on the third day from Sabouraud Dextrose Agar supplemented with chloramphenicol and gentamicin. Antifungal susceptibility test revealed that 5-fluorocytosine was the most active drug against M. capitatus, followed by itraconazole and voriconazole, micafungin, amphotericin B and fluconazole, posaconazole, anidulafungin, and caspofungin. Our data showed the importance of an early cultural and fast microbiology diagnosis based on the characteristic morphologic features observed in Gram-stained smears of blood culture positive bottles, and the validation via MALDI-TOF MS. This dual approach has significant impact in the clinical management of infectious diseases and antibiotic stewardship, by integrating sample processing, fluid handling, and detection for rapid bacterial diagnosis. |
| first_indexed | 2024-04-24T07:05:29Z |
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| institution | Directory Open Access Journal |
| issn | 2214-2509 |
| language | English |
| last_indexed | 2025-03-21T17:33:13Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj.art-808ec5def02b4a8f9e0389bc35f4674b2024-06-13T04:44:24ZengElsevierIDCases2214-25092024-01-0136e01959A case of Magnusiomyces capitatus isolated during monitoring in an antimicrobial diagnostic stewardship context.Francesco Foglia0Giuseppe Greco1Carla Zannella2Annalisa Chianese3Annalisa Ambrosino4Alessandra Conzo5Giovanni Conzo6Anna De Filippis7Emiliana Finamore8Ludovico Docimo9Massimiliano Galdiero10Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, University of Campania ''Luigi Vanvitelli'', 80138 Naples, ItalyDepartment of Experimental Medicine, Section of Microbiology and Clinical Microbiology, University of Campania ''Luigi Vanvitelli'', 80138 Naples, ItalyDepartment of Experimental Medicine, Section of Microbiology and Clinical Microbiology, University of Campania ''Luigi Vanvitelli'', 80138 Naples, ItalyDepartment of Experimental Medicine, Section of Microbiology and Clinical Microbiology, University of Campania ''Luigi Vanvitelli'', 80138 Naples, ItalyDepartment of Experimental Medicine, Section of Microbiology and Clinical Microbiology, University of Campania ''Luigi Vanvitelli'', 80138 Naples, ItalyDivision of General and Oncologic Surgery, Department of Cardiothoracic Sciences, University of Campania ''Luigi Vanvitelli'', Via Pansini 1, 80131 Naples, ItalyDivision of General and Oncologic Surgery, Department of Cardiothoracic Sciences, University of Campania ''Luigi Vanvitelli'', Via Pansini 1, 80131 Naples, ItalyDepartment of Experimental Medicine, Section of Microbiology and Clinical Microbiology, University of Campania ''Luigi Vanvitelli'', 80138 Naples, ItalyComplex Operative Unity of Virology and Microbiology, University Hospital of Campania ''Luigi Vanvitelli'', 80138 Naples, Italy; Corresponding author.Division of General and Oncologic Surgery, Department of Cardiothoracic Sciences, University of Campania ''Luigi Vanvitelli'', Via Pansini 1, 80131 Naples, ItalyDepartment of Experimental Medicine, Section of Microbiology and Clinical Microbiology, University of Campania ''Luigi Vanvitelli'', 80138 Naples, Italy; Complex Operative Unity of Virology and Microbiology, University Hospital of Campania ''Luigi Vanvitelli'', 80138 Naples, ItalyMagnusiomyces capitatus (M. capitatus) is an emerging opportunistic yeast in the Mediterranean region typically isolated from immunocompromised patients, usually affected by blood malignancies. We reported a rare case of M. capitatus infection, isolated from a drainage fluid in a patient affected by lung cancer recovered in the University Hospital of Campania “Luigi Vanvitelli”, Naples, Italy. The isolate was identified by phenotypic methods, i.e., Gram and Lactophenol cotton blue (LCB) staining, and matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) analysis. We identified M. capitatus on the third day from Sabouraud Dextrose Agar supplemented with chloramphenicol and gentamicin. Antifungal susceptibility test revealed that 5-fluorocytosine was the most active drug against M. capitatus, followed by itraconazole and voriconazole, micafungin, amphotericin B and fluconazole, posaconazole, anidulafungin, and caspofungin. Our data showed the importance of an early cultural and fast microbiology diagnosis based on the characteristic morphologic features observed in Gram-stained smears of blood culture positive bottles, and the validation via MALDI-TOF MS. This dual approach has significant impact in the clinical management of infectious diseases and antibiotic stewardship, by integrating sample processing, fluid handling, and detection for rapid bacterial diagnosis.http://www.sciencedirect.com/science/article/pii/S2214250924000350Magnusiomyces capitatusAntimicrobial Diagnostic StewardshipSurveillanceYeast infection |
| spellingShingle | Francesco Foglia Giuseppe Greco Carla Zannella Annalisa Chianese Annalisa Ambrosino Alessandra Conzo Giovanni Conzo Anna De Filippis Emiliana Finamore Ludovico Docimo Massimiliano Galdiero A case of Magnusiomyces capitatus isolated during monitoring in an antimicrobial diagnostic stewardship context. IDCases Magnusiomyces capitatus Antimicrobial Diagnostic Stewardship Surveillance Yeast infection |
| title | A case of Magnusiomyces capitatus isolated during monitoring in an antimicrobial diagnostic stewardship context. |
| title_full | A case of Magnusiomyces capitatus isolated during monitoring in an antimicrobial diagnostic stewardship context. |
| title_fullStr | A case of Magnusiomyces capitatus isolated during monitoring in an antimicrobial diagnostic stewardship context. |
| title_full_unstemmed | A case of Magnusiomyces capitatus isolated during monitoring in an antimicrobial diagnostic stewardship context. |
| title_short | A case of Magnusiomyces capitatus isolated during monitoring in an antimicrobial diagnostic stewardship context. |
| title_sort | case of magnusiomyces capitatus isolated during monitoring in an antimicrobial diagnostic stewardship context |
| topic | Magnusiomyces capitatus Antimicrobial Diagnostic Stewardship Surveillance Yeast infection |
| url | http://www.sciencedirect.com/science/article/pii/S2214250924000350 |
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