Brain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys
A comprehensive anatomically-defined atlas of brain transcriptomics in macaques is still lacking. Here, the authors generate complementary bulk RNA-seq and snRNA-seq datasets from cynomolgus macaques to examine the link between brain-wide gene expression and regional variation in morphometry.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37246-w |
| _version_ | 1797864091669233664 |
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| author | Tingting Bo Jie Li Ganlu Hu Ge Zhang Wei Wang Qian Lv Shaoling Zhao Junjie Ma Meng Qin Xiaohui Yao Meiyun Wang Guang-Zhong Wang Zheng Wang |
| author_facet | Tingting Bo Jie Li Ganlu Hu Ge Zhang Wei Wang Qian Lv Shaoling Zhao Junjie Ma Meng Qin Xiaohui Yao Meiyun Wang Guang-Zhong Wang Zheng Wang |
| author_sort | Tingting Bo |
| collection | DOAJ |
| description | A comprehensive anatomically-defined atlas of brain transcriptomics in macaques is still lacking. Here, the authors generate complementary bulk RNA-seq and snRNA-seq datasets from cynomolgus macaques to examine the link between brain-wide gene expression and regional variation in morphometry. |
| first_indexed | 2024-04-09T22:47:03Z |
| format | Article |
| id | doaj.art-80902548f9714a31a09d2c6c95a8f084 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:47:03Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-80902548f9714a31a09d2c6c95a8f0842023-03-22T11:49:07ZengNature PortfolioNature Communications2041-17232023-03-0114111510.1038/s41467-023-37246-wBrain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeysTingting Bo0Jie Li1Ganlu Hu2Ge Zhang3Wei Wang4Qian Lv5Shaoling Zhao6Junjie Ma7Meng Qin8Xiaohui Yao9Meiyun Wang10Guang-Zhong Wang11Zheng Wang12Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of SciencesShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech UniversityDepartment of Medical Imaging, Henan Provincial People’s Hospital & the People’s Hospital of Zhengzhou UniversityCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of SciencesSchool of Psychological and Cognitive Sciences; Beijing Key Laboratory of Behavior and Mental Health; IDG/McGovern Institute for Brain Research; Peking-Tsinghua Center for Life Sciences, Peking UniversityInstitute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, State Key Laboratory of Neuroscience, Chinese Academy of SciencesCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of SciencesCollege of Life Science and Technology, Beijing University of Chemical TechnologyQingdao Innovation and Development Center, Harbin Engineering UniversityDepartment of Medical Imaging, Henan Provincial People’s Hospital & the People’s Hospital of Zhengzhou UniversityCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of SciencesSchool of Psychological and Cognitive Sciences; Beijing Key Laboratory of Behavior and Mental Health; IDG/McGovern Institute for Brain Research; Peking-Tsinghua Center for Life Sciences, Peking UniversityA comprehensive anatomically-defined atlas of brain transcriptomics in macaques is still lacking. Here, the authors generate complementary bulk RNA-seq and snRNA-seq datasets from cynomolgus macaques to examine the link between brain-wide gene expression and regional variation in morphometry.https://doi.org/10.1038/s41467-023-37246-w |
| spellingShingle | Tingting Bo Jie Li Ganlu Hu Ge Zhang Wei Wang Qian Lv Shaoling Zhao Junjie Ma Meng Qin Xiaohui Yao Meiyun Wang Guang-Zhong Wang Zheng Wang Brain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys Nature Communications |
| title | Brain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys |
| title_full | Brain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys |
| title_fullStr | Brain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys |
| title_full_unstemmed | Brain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys |
| title_short | Brain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys |
| title_sort | brain wide and cell specific transcriptomic insights into mri derived cortical morphology in macaque monkeys |
| url | https://doi.org/10.1038/s41467-023-37246-w |
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