The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications
Solubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, and anti-solvents in the synthesis and crysta...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/21/8298 |
| _version_ | 1797548755370639360 |
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| author | Sónia N. Pedro Carmen S. R. Freire Armando J. D. Silvestre Mara G. Freire |
| author_facet | Sónia N. Pedro Carmen S. R. Freire Armando J. D. Silvestre Mara G. Freire |
| author_sort | Sónia N. Pedro |
| collection | DOAJ |
| description | Solubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, and anti-solvents in the synthesis and crystallization of active pharmaceutical ingredients (APIs), as solvents, co-solvents and emulsifiers in drug formulations, as pharmaceuticals (API-ILs) aiming liquid therapeutics, and in the development and/or improvement of drug-delivery-based systems. The present review focuses on the use of ILs in the pharmaceutical field, covering their multiple applications from pharmaceutical synthesis to drug delivery. The most relevant research conducted up to date is presented and discussed, together with a critical analysis of the most significant IL-based strategies in order to improve the performance of therapeutics and drug delivery systems. |
| first_indexed | 2024-03-10T15:04:11Z |
| format | Article |
| id | doaj.art-8090fa4d11e9402594ec388dfee76100 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:04:11Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8090fa4d11e9402594ec388dfee761002023-11-20T19:54:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-012121829810.3390/ijms21218298The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant ApplicationsSónia N. Pedro0Carmen S. R. Freire1Armando J. D. Silvestre2Mara G. Freire3Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, PortugalDepartment of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, PortugalDepartment of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, PortugalDepartment of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, PortugalSolubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, and anti-solvents in the synthesis and crystallization of active pharmaceutical ingredients (APIs), as solvents, co-solvents and emulsifiers in drug formulations, as pharmaceuticals (API-ILs) aiming liquid therapeutics, and in the development and/or improvement of drug-delivery-based systems. The present review focuses on the use of ILs in the pharmaceutical field, covering their multiple applications from pharmaceutical synthesis to drug delivery. The most relevant research conducted up to date is presented and discussed, together with a critical analysis of the most significant IL-based strategies in order to improve the performance of therapeutics and drug delivery systems.https://www.mdpi.com/1422-0067/21/21/8298active pharmaceutical ingredientsdrug delivery systemsformulationsionic liquidssolubilitypermeability |
| spellingShingle | Sónia N. Pedro Carmen S. R. Freire Armando J. D. Silvestre Mara G. Freire The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications International Journal of Molecular Sciences active pharmaceutical ingredients drug delivery systems formulations ionic liquids solubility permeability |
| title | The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications |
| title_full | The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications |
| title_fullStr | The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications |
| title_full_unstemmed | The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications |
| title_short | The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications |
| title_sort | role of ionic liquids in the pharmaceutical field an overview of relevant applications |
| topic | active pharmaceutical ingredients drug delivery systems formulations ionic liquids solubility permeability |
| url | https://www.mdpi.com/1422-0067/21/21/8298 |
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