Emerging Concepts of Motor Reserve in Parkinson’s Disease
The concept of cognitive reserve (CR) in Alzheimer’s disease (AD) explains the differences between individuals in their susceptibility to AD-related pathologies. An enhanced CR may lead to less cognitive deficits despite severe pathological lesions. Parkinson’s disease (PD) is also a common neurodeg...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Korean Movement Disorder Society
2020-09-01
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| Series: | Journal of Movement Disorders |
| Subjects: | |
| Online Access: | http://www.e-jmd.org/upload/jmd-20029.pdf |
| _version_ | 1827842796429508608 |
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| author | Seok Jong Chung Jae Jung Lee Phil Hyu Lee Young H. Sohn |
| author_facet | Seok Jong Chung Jae Jung Lee Phil Hyu Lee Young H. Sohn |
| author_sort | Seok Jong Chung |
| collection | DOAJ |
| description | The concept of cognitive reserve (CR) in Alzheimer’s disease (AD) explains the differences between individuals in their susceptibility to AD-related pathologies. An enhanced CR may lead to less cognitive deficits despite severe pathological lesions. Parkinson’s disease (PD) is also a common neurodegenerative disease and is mainly characterized by motor dysfunction related to striatal dopaminergic depletion. The degree of motor deficits in PD is closely correlated to the degree of dopamine depletion; however, significant individual variations still exist. Therefore, we hypothesized that the presence of motor reserve (MR) in PD explains the individual differences in motor deficits despite similar levels of striatal dopamine depletion. Since 2015, we have performed a series of studies investigating MR in de novo patients with PD using the data of initial clinical presentation and dopamine transporter PET scan. In this review, we summarized the results of these published studies. In particular, some premorbid experiences (i.e., physical activity and education) and modifiable factors (i.e., body mass index and white matter hyperintensity on brain image studies) could modulate an individual’s capacity to tolerate PD pathology, which can be maintained throughout disease progression. |
| first_indexed | 2024-03-12T08:15:54Z |
| format | Article |
| id | doaj.art-80910d61263f4fad99c45a2d3f9732ee |
| institution | Directory Open Access Journal |
| issn | 2005-940X 2093-4939 |
| language | English |
| last_indexed | 2024-03-12T08:15:54Z |
| publishDate | 2020-09-01 |
| publisher | Korean Movement Disorder Society |
| record_format | Article |
| series | Journal of Movement Disorders |
| spelling | doaj.art-80910d61263f4fad99c45a2d3f9732ee2023-09-02T18:56:15ZengKorean Movement Disorder SocietyJournal of Movement Disorders2005-940X2093-49392020-09-0113317118410.14802/jmd.20029298Emerging Concepts of Motor Reserve in Parkinson’s DiseaseSeok Jong Chung0Jae Jung Lee1Phil Hyu Lee2Young H. Sohn3 Department of Neurology, Yonsei University College of Medicine, Seoul, Korea Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea Department of Neurology, Yonsei University College of Medicine, Seoul, Korea Department of Neurology, Yonsei University College of Medicine, Seoul, KoreaThe concept of cognitive reserve (CR) in Alzheimer’s disease (AD) explains the differences between individuals in their susceptibility to AD-related pathologies. An enhanced CR may lead to less cognitive deficits despite severe pathological lesions. Parkinson’s disease (PD) is also a common neurodegenerative disease and is mainly characterized by motor dysfunction related to striatal dopaminergic depletion. The degree of motor deficits in PD is closely correlated to the degree of dopamine depletion; however, significant individual variations still exist. Therefore, we hypothesized that the presence of motor reserve (MR) in PD explains the individual differences in motor deficits despite similar levels of striatal dopamine depletion. Since 2015, we have performed a series of studies investigating MR in de novo patients with PD using the data of initial clinical presentation and dopamine transporter PET scan. In this review, we summarized the results of these published studies. In particular, some premorbid experiences (i.e., physical activity and education) and modifiable factors (i.e., body mass index and white matter hyperintensity on brain image studies) could modulate an individual’s capacity to tolerate PD pathology, which can be maintained throughout disease progression.http://www.e-jmd.org/upload/jmd-20029.pdfdopamine transportermotor reserveparkinson’s diseasepositron-emission tomography |
| spellingShingle | Seok Jong Chung Jae Jung Lee Phil Hyu Lee Young H. Sohn Emerging Concepts of Motor Reserve in Parkinson’s Disease Journal of Movement Disorders dopamine transporter motor reserve parkinson’s disease positron-emission tomography |
| title | Emerging Concepts of Motor Reserve in Parkinson’s Disease |
| title_full | Emerging Concepts of Motor Reserve in Parkinson’s Disease |
| title_fullStr | Emerging Concepts of Motor Reserve in Parkinson’s Disease |
| title_full_unstemmed | Emerging Concepts of Motor Reserve in Parkinson’s Disease |
| title_short | Emerging Concepts of Motor Reserve in Parkinson’s Disease |
| title_sort | emerging concepts of motor reserve in parkinson s disease |
| topic | dopamine transporter motor reserve parkinson’s disease positron-emission tomography |
| url | http://www.e-jmd.org/upload/jmd-20029.pdf |
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