Androgen effect on connexin expression in the mammalian female reproductive system: A systematic review
The functions of androgen and connexin in the mammalian female reproductive system are suggested to be related. Previous research has shown that androgen affects connexin expression in the female reproductive system, altering its function. However, no definitive conclusion on their cause-effect rel...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2020-08-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/4501 |
| _version_ | 1797260949618425856 |
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| author | Datu Agasi Mohd Kamal Siti Fatimah Ibrahim Mohd Helmy Mokhtar |
| author_facet | Datu Agasi Mohd Kamal Siti Fatimah Ibrahim Mohd Helmy Mokhtar |
| author_sort | Datu Agasi Mohd Kamal |
| collection | DOAJ |
| description |
The functions of androgen and connexin in the mammalian female reproductive system are suggested to be related. Previous research has shown that androgen affects connexin expression in the female reproductive system, altering its function. However, no definitive conclusion on their cause-effect relationship has been drawn yet. In addition, a high prevalence of women with polycystic ovary syndrome (PCOS), who are characterized by elevated androgen levels and failure of ovulation, has prompted the studies on the relationship between androgen and connexin in the ovaries. This systematic review aims to investigate the effect of androgen on connexin expression in the mammalian female reproductive system. The literature search was conducted using the MEDLINE via EBSCOhost and the Scopus database and the following keywords: “androgen” or “testosterone” or “androgen blocker” or “anti-androgen” or “androstenedione” or “dehydroepiandrosterone” or “flutamide AND connexin” or “gap junction” or “cell junction”. We only considered in vitro and in vivo studies that involved treatment by androgen or androgen receptor blockers and measured connexin expression as one of the parameters. Our review showed that the exposure to androgen or androgen blocker affects connexin expression but not its localization in the mammalian ovary. However, it is not clear whether androgen downregulates or upregulates connexin expression.
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| first_indexed | 2024-04-24T23:33:27Z |
| format | Article |
| id | doaj.art-8091d18ef8dd45a0a25335a4f25d637c |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:33:27Z |
| publishDate | 2020-08-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-8091d18ef8dd45a0a25335a4f25d637c2024-03-15T14:30:00ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2020-08-0120310.17305/bjbms.2019.4501Androgen effect on connexin expression in the mammalian female reproductive system: A systematic reviewDatu Agasi Mohd Kamal0https://orcid.org/0000-0003-0836-9702Siti Fatimah Ibrahim1https://orcid.org/0000-0002-4474-8032Mohd Helmy Mokhtar2https://orcid.org/0000-0002-7801-6358Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, MalaysiaDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, MalaysiaDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia The functions of androgen and connexin in the mammalian female reproductive system are suggested to be related. Previous research has shown that androgen affects connexin expression in the female reproductive system, altering its function. However, no definitive conclusion on their cause-effect relationship has been drawn yet. In addition, a high prevalence of women with polycystic ovary syndrome (PCOS), who are characterized by elevated androgen levels and failure of ovulation, has prompted the studies on the relationship between androgen and connexin in the ovaries. This systematic review aims to investigate the effect of androgen on connexin expression in the mammalian female reproductive system. The literature search was conducted using the MEDLINE via EBSCOhost and the Scopus database and the following keywords: “androgen” or “testosterone” or “androgen blocker” or “anti-androgen” or “androstenedione” or “dehydroepiandrosterone” or “flutamide AND connexin” or “gap junction” or “cell junction”. We only considered in vitro and in vivo studies that involved treatment by androgen or androgen receptor blockers and measured connexin expression as one of the parameters. Our review showed that the exposure to androgen or androgen blocker affects connexin expression but not its localization in the mammalian ovary. However, it is not clear whether androgen downregulates or upregulates connexin expression. https://www.bjbms.org/ojs/index.php/bjbms/article/view/4501Androgenandrogen blockerconnexinovaryfemale reproductive system |
| spellingShingle | Datu Agasi Mohd Kamal Siti Fatimah Ibrahim Mohd Helmy Mokhtar Androgen effect on connexin expression in the mammalian female reproductive system: A systematic review Biomolecules & Biomedicine Androgen androgen blocker connexin ovary female reproductive system |
| title | Androgen effect on connexin expression in the mammalian female reproductive system: A systematic review |
| title_full | Androgen effect on connexin expression in the mammalian female reproductive system: A systematic review |
| title_fullStr | Androgen effect on connexin expression in the mammalian female reproductive system: A systematic review |
| title_full_unstemmed | Androgen effect on connexin expression in the mammalian female reproductive system: A systematic review |
| title_short | Androgen effect on connexin expression in the mammalian female reproductive system: A systematic review |
| title_sort | androgen effect on connexin expression in the mammalian female reproductive system a systematic review |
| topic | Androgen androgen blocker connexin ovary female reproductive system |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/4501 |
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