Valproic acid silencing of ascl1b/Ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome

Valproic acid silencing of ascl1b/Ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome

Fetal valproate syndrome (FVS) is caused by in utero exposure to the drug sodium valproate. Valproate is used worldwide for the treatment of epilepsy, as a mood stabiliser and for its pain-relieving properties. In addition to birth defects, FVS is associated with an increased risk of autism spectrum...

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Bibliographic Details
Main Authors: John Jacob, Vanessa Ribes, Steven Moore, Sean C. Constable, Noriaki Sasai, Sebastian S. Gerety, Darren J. Martin, Chris P. Sergeant, David G. Wilkinson, James Briscoe
Format: Article
Language:English
Published: The Company of Biologists 2014-01-01
Series:Disease Models & Mechanisms
Subjects:
Serotonin
Fetal valproate syndrome
Zebrafish
Notch
Proneural gene
Hdac1
Online Access:http://dmm.biologists.org/content/7/1/107

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