Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is considered one of the most aggressive tumors worldwide. The consumption of lipid-enriched diets, mainly high cholesterol, induces oxidative stress and chronic inflammation, leading to HCC progression. Moreover, fatty acids and cholesterol could display differential...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2022-07-01
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| Series: | Exploration of Digestive Diseases |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/Journals/edd/Article/10053 |
| _version_ | 1797845546246864896 |
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| author | Alejandro Escobedo-Calvario Lisette Chávez-Rodríguez Arturo Simoni-Nieves Verónica Souza-Arroyo Roxana U. Miranda-Labra Luis E. Gomez-Quiroz María Concepción Gutiérrez-Ruíz |
| author_facet | Alejandro Escobedo-Calvario Lisette Chávez-Rodríguez Arturo Simoni-Nieves Verónica Souza-Arroyo Roxana U. Miranda-Labra Luis E. Gomez-Quiroz María Concepción Gutiérrez-Ruíz |
| author_sort | Alejandro Escobedo-Calvario |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is considered one of the most aggressive tumors worldwide. The consumption of lipid-enriched diets, mainly high cholesterol, induces oxidative stress and chronic inflammation, leading to HCC progression. Moreover, fatty acids and cholesterol could display differential responses on immune cells inside the tumor immune microenvironment (TIME). Tumor-associated macrophages (TAMs) represent one of the most critical leukocytes in the tumor microenvironment (TME) displaying pro-tumoral responses and one of the mainly cholesterol donors to cancer cells. Immunotherapy or cholesterol regulators, alone or combined, would represent an effective strategy for HCC treatment. Nonetheless, steatotic etiology from non-alcoholic fatty liver disease (NAFLD)-HCC tumors has been unexpectedly resulting in highly aggressive behavior. |
| first_indexed | 2024-04-09T17:40:45Z |
| format | Article |
| id | doaj.art-809344338ae944b6aafe031693a88b8e |
| institution | Directory Open Access Journal |
| issn | 2833-6321 |
| language | English |
| last_indexed | 2024-04-09T17:40:45Z |
| publishDate | 2022-07-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Digestive Diseases |
| spelling | doaj.art-809344338ae944b6aafe031693a88b8e2023-04-17T05:26:18ZengOpen Exploration Publishing Inc.Exploration of Digestive Diseases2833-63212022-07-01112139https://doi.org/10.37349/edd.2022.00003Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinomaAlejandro Escobedo-Calvario 0https://orcid.org/0000-0002-8978-3122Lisette Chávez-Rodríguez 1https://orcid.org/0000-0002-6678-0877Arturo Simoni-Nieves2https://orcid.org/0000-0002-1353-260XVerónica Souza-Arroyo3https://orcid.org/0000-0002-3923-6278Roxana U. Miranda-Labra 4https://orcid.org/0000-0001-8249-7257Luis E. Gomez-Quiroz5https://orcid.org/0000-0002-5704-5985María Concepción Gutiérrez-Ruíz6https://orcid.org/0000-0003-0501-7226Posgrado en Biología Experimental, DCBS, Universidad Autónoma Metrolitana-Iztapalapa, Mexico City 09340, Mexico; Área de Medicina Experimental y Traslacional, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, MexicoPosgrado en Biología Experimental, DCBS, Universidad Autónoma Metrolitana-Iztapalapa, Mexico City 09340, Mexico; Área de Medicina Experimental y Traslacional, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, MexicoÁrea de Medicina Experimental y Traslacional, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, IsraeÁrea de Medicina Experimental y Traslacional, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico; Laboratorio de Medicina Experimental, Unidad de Medicina Traslacional IIB/UNAM, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoÁrea de Medicina Experimental y Traslacional, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico; Laboratorio de Medicina Experimental, Unidad de Medicina Traslacional IIB/UNAM, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoÁrea de Medicina Experimental y Traslacional, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico; Laboratorio de Medicina Experimental, Unidad de Medicina Traslacional IIB/UNAM, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoÁrea de Medicina Experimental y Traslacional, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico; Laboratorio de Medicina Experimental, Unidad de Medicina Traslacional IIB/UNAM, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoHepatocellular carcinoma (HCC) is considered one of the most aggressive tumors worldwide. The consumption of lipid-enriched diets, mainly high cholesterol, induces oxidative stress and chronic inflammation, leading to HCC progression. Moreover, fatty acids and cholesterol could display differential responses on immune cells inside the tumor immune microenvironment (TIME). Tumor-associated macrophages (TAMs) represent one of the most critical leukocytes in the tumor microenvironment (TME) displaying pro-tumoral responses and one of the mainly cholesterol donors to cancer cells. Immunotherapy or cholesterol regulators, alone or combined, would represent an effective strategy for HCC treatment. Nonetheless, steatotic etiology from non-alcoholic fatty liver disease (NAFLD)-HCC tumors has been unexpectedly resulting in highly aggressive behavior.https://www.explorationpub.com/Journals/edd/Article/10053hepatocellular carcinomacholesterolinflammationimmune cellsmacrophages |
| spellingShingle | Alejandro Escobedo-Calvario Lisette Chávez-Rodríguez Arturo Simoni-Nieves Verónica Souza-Arroyo Roxana U. Miranda-Labra Luis E. Gomez-Quiroz María Concepción Gutiérrez-Ruíz Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma Exploration of Digestive Diseases hepatocellular carcinoma cholesterol inflammation immune cells macrophages |
| title | Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma |
| title_full | Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma |
| title_fullStr | Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma |
| title_full_unstemmed | Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma |
| title_short | Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma |
| title_sort | tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma |
| topic | hepatocellular carcinoma cholesterol inflammation immune cells macrophages |
| url | https://www.explorationpub.com/Journals/edd/Article/10053 |
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