Undiagnosed Hypothyroidism in Obstructive Sleep Apnea Syndrome
Objective Lethargy, apathy, daytime sleepiness are common features of Obstructive sleep apnea syndrome (OSAS). These features are already seen in hypothyroidism. OSAS is more frequent in obese patients and overt hypothyroidism may substantially add to this risk. We aimed to evaluate the incidence o...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2015-03-01
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| Series: | Türk Uyku Tıbbı Dergisi |
| Subjects: | |
| Online Access: | http://jtsm.org/archives/archive-detail/article-preview/undiagnosed-hypothyroidism-in-obstructive-sleep-ap/10246 |
| _version_ | 1828025056606814208 |
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| author | Elif Torun Parmaksiz Banu Salepçi Gülsen Saraç Nesrin Kiral Ali Fidan Sevda Cömert Benan Çaglayan |
| author_facet | Elif Torun Parmaksiz Banu Salepçi Gülsen Saraç Nesrin Kiral Ali Fidan Sevda Cömert Benan Çaglayan |
| author_sort | Elif Torun Parmaksiz |
| collection | DOAJ |
| description | Objective
Lethargy, apathy, daytime sleepiness are common features of Obstructive sleep apnea syndrome (OSAS). These features are already seen in hypothyroidism. OSAS is more frequent in obese patients and overt hypothyroidism may substantially add to this risk. We aimed to evaluate the incidence of hypothyroidism in cases applying with OSAS symptoms who have no known clinical thyroid disease to evaluate the necessity of thyroid hormone screening in OSAS.
Materials and Methods
The study population consisted of patients with no known history of thyroid disease. All patients were screened in the sleep laboratory for one night and polysomnography. Serum thyroid-stimulating hormone (TSH) levels were measured by chemiluminescence method in patients referred to our sleep center for an overnight sleep study.
Results
Of 1473 subjects, 1406 (95.5%) were diagnosed as OSA (Apnea-hypopnea index (AHI)>5). Elevated TSH levels were detected in 3 cases in the nonapneic group (4.47%) and 54 cases in the OSAS group (3.90%). In mild-moderate OSAS group, the mean TSH value was 2.02 µU /ml and in patients with severe OSAS this value was 2.44 µU/ml, though the difference was not statistically significant (p=0.08). AHI was found to be weakly correlated with TSH values, though the correlation was statistically significant (r=0.05, p=0.04). Mean TSH values were not correlated with oxygen desaturation index (ODI) or lowest oxygen saturation values (r=0.02 and r=-0.02, respectively).
Conclusion
The measurement of TSH levels in suspected OSAS cases may help both differential diagnosis between OSAS and hypothyroidism, but subclinical hypothyroidism was not found more common in patients with OSAS. |
| first_indexed | 2024-04-10T12:53:55Z |
| format | Article |
| id | doaj.art-8093b6a92efe431dabaa52d4d400ec3c |
| institution | Directory Open Access Journal |
| issn | 2148-1504 |
| language | English |
| last_indexed | 2024-04-10T12:53:55Z |
| publishDate | 2015-03-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Uyku Tıbbı Dergisi |
| spelling | doaj.art-8093b6a92efe431dabaa52d4d400ec3c2023-02-15T16:13:35ZengGalenos YayineviTürk Uyku Tıbbı Dergisi2148-15042015-03-0121111410.4274/jtsm.02.003Undiagnosed Hypothyroidism in Obstructive Sleep Apnea SyndromeElif Torun Parmaksiz0Banu Salepçi1Gülsen Saraç2Nesrin Kiral3Ali Fidan4Sevda Cömert5Benan Çaglayan6Dr. Lütfi Kirdar Kartal Training Hospital, Clinic Of Pulmonary Diseases, Istanbul, TurkeyDr. Lütfi Kirdar Kartal Training Hospital, Clinic Of Pulmonary Diseases, Istanbul, TurkeyDr. Lütfi Kirdar Kartal Training Hospital, Clinic Of Pulmonary Diseases, Istanbul, TurkeyDr. Lütfi Kirdar Kartal Training Hospital, Clinic Of Pulmonary Diseases, Istanbul, TurkeyDr. Lütfi Kirdar Kartal Training Hospital, Clinic Of Pulmonary Diseases, Istanbul, TurkeyDr. Lütfi Kirdar Kartal Training Hospital, Clinic Of Pulmonary Diseases, Istanbul, TurkeyDr. Lütfi Kirdar Kartal Training Hospital, Clinic Of Pulmonary Diseases, Istanbul, TurkeyObjective Lethargy, apathy, daytime sleepiness are common features of Obstructive sleep apnea syndrome (OSAS). These features are already seen in hypothyroidism. OSAS is more frequent in obese patients and overt hypothyroidism may substantially add to this risk. We aimed to evaluate the incidence of hypothyroidism in cases applying with OSAS symptoms who have no known clinical thyroid disease to evaluate the necessity of thyroid hormone screening in OSAS. Materials and Methods The study population consisted of patients with no known history of thyroid disease. All patients were screened in the sleep laboratory for one night and polysomnography. Serum thyroid-stimulating hormone (TSH) levels were measured by chemiluminescence method in patients referred to our sleep center for an overnight sleep study. Results Of 1473 subjects, 1406 (95.5%) were diagnosed as OSA (Apnea-hypopnea index (AHI)>5). Elevated TSH levels were detected in 3 cases in the nonapneic group (4.47%) and 54 cases in the OSAS group (3.90%). In mild-moderate OSAS group, the mean TSH value was 2.02 µU /ml and in patients with severe OSAS this value was 2.44 µU/ml, though the difference was not statistically significant (p=0.08). AHI was found to be weakly correlated with TSH values, though the correlation was statistically significant (r=0.05, p=0.04). Mean TSH values were not correlated with oxygen desaturation index (ODI) or lowest oxygen saturation values (r=0.02 and r=-0.02, respectively). Conclusion The measurement of TSH levels in suspected OSAS cases may help both differential diagnosis between OSAS and hypothyroidism, but subclinical hypothyroidism was not found more common in patients with OSAS.http://jtsm.org/archives/archive-detail/article-preview/undiagnosed-hypothyroidism-in-obstructive-sleep-ap/10246Obstructive sleep apnea syndromesubclinical hypothyroidismthyroid-stimulating hormone |
| spellingShingle | Elif Torun Parmaksiz Banu Salepçi Gülsen Saraç Nesrin Kiral Ali Fidan Sevda Cömert Benan Çaglayan Undiagnosed Hypothyroidism in Obstructive Sleep Apnea Syndrome Türk Uyku Tıbbı Dergisi Obstructive sleep apnea syndrome subclinical hypothyroidism thyroid-stimulating hormone |
| title | Undiagnosed Hypothyroidism in Obstructive Sleep Apnea Syndrome |
| title_full | Undiagnosed Hypothyroidism in Obstructive Sleep Apnea Syndrome |
| title_fullStr | Undiagnosed Hypothyroidism in Obstructive Sleep Apnea Syndrome |
| title_full_unstemmed | Undiagnosed Hypothyroidism in Obstructive Sleep Apnea Syndrome |
| title_short | Undiagnosed Hypothyroidism in Obstructive Sleep Apnea Syndrome |
| title_sort | undiagnosed hypothyroidism in obstructive sleep apnea syndrome |
| topic | Obstructive sleep apnea syndrome subclinical hypothyroidism thyroid-stimulating hormone |
| url | http://jtsm.org/archives/archive-detail/article-preview/undiagnosed-hypothyroidism-in-obstructive-sleep-ap/10246 |
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