Structural and Molecular Basis for Mitochondrial DNA Replication and Transcription in Health and Antiviral Drug Toxicity

Structural and Molecular Basis for Mitochondrial DNA Replication and Transcription in Health and Antiviral Drug Toxicity

Human mitochondrial DNA (mtDNA) is a 16.9 kbp double-stranded, circular DNA, encoding subunits of the oxidative phosphorylation electron transfer chain and essential RNAs for mitochondrial protein translation. The minimal human mtDNA replisome is composed of the DNA helicase Twinkle, DNA polymerase...

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Bibliographic Details
Main Authors: Joon Park, Noe Baruch-Torres, Y. Whitney Yin
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
mitochondria
DNA replication
RNA transcription
human diseases
antivirals
HIV
Online Access:https://www.mdpi.com/1420-3049/28/4/1796

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