MicroRNA Functions in Thymic Biology: Thymic Development and Involution
During the entire processes of thymus organogenesis, maturation, and involution, gene regulation occurs post-transcriptionally via recently discovered microRNA (miRNA) transcripts. Numerous reports indicate that miRNAs may be involved in the construction of a normal thymic microenvironment, which co...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02063/full |
| _version_ | 1818500918240346112 |
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| author | Minwen Xu Tao Gan Huiting Ning Liefeng Wang |
| author_facet | Minwen Xu Tao Gan Huiting Ning Liefeng Wang |
| author_sort | Minwen Xu |
| collection | DOAJ |
| description | During the entire processes of thymus organogenesis, maturation, and involution, gene regulation occurs post-transcriptionally via recently discovered microRNA (miRNA) transcripts. Numerous reports indicate that miRNAs may be involved in the construction of a normal thymic microenvironment, which constitutes a critical component to support T lymphocyte development. MiRNAs are also expressed in thymic stromal cells including thymic epithelial cells (TECs) during maturation and senescence. This review focuses on the function of miRNAs in thymic development and involution. A better understanding of these processes will provide new insights into the regulatory network of TECs and further comprehension of how genes control TECs to maintain the thymic microenvironment during thymus development and aging, thus supporting a normal cellular immune system. |
| first_indexed | 2024-12-10T20:49:09Z |
| format | Article |
| id | doaj.art-809536e330ff4a9b9019b7cb91cf4d99 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T20:49:09Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-809536e330ff4a9b9019b7cb91cf4d992022-12-22T01:34:09ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-09-01910.3389/fimmu.2018.02063301503MicroRNA Functions in Thymic Biology: Thymic Development and InvolutionMinwen Xu0Tao Gan1Huiting Ning2Liefeng Wang3First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Biotechnology, Gannan Medical University, Ganzhou, ChinaDepartment of Biotechnology, Gannan Medical University, Ganzhou, ChinaDepartment of Biotechnology, Gannan Medical University, Ganzhou, ChinaDuring the entire processes of thymus organogenesis, maturation, and involution, gene regulation occurs post-transcriptionally via recently discovered microRNA (miRNA) transcripts. Numerous reports indicate that miRNAs may be involved in the construction of a normal thymic microenvironment, which constitutes a critical component to support T lymphocyte development. MiRNAs are also expressed in thymic stromal cells including thymic epithelial cells (TECs) during maturation and senescence. This review focuses on the function of miRNAs in thymic development and involution. A better understanding of these processes will provide new insights into the regulatory network of TECs and further comprehension of how genes control TECs to maintain the thymic microenvironment during thymus development and aging, thus supporting a normal cellular immune system.https://www.frontiersin.org/article/10.3389/fimmu.2018.02063/fullmicroRNAthymic epithelial cellsthymic developmentthymic involutionthymic microenvironmentthymus aging |
| spellingShingle | Minwen Xu Tao Gan Huiting Ning Liefeng Wang MicroRNA Functions in Thymic Biology: Thymic Development and Involution Frontiers in Immunology microRNA thymic epithelial cells thymic development thymic involution thymic microenvironment thymus aging |
| title | MicroRNA Functions in Thymic Biology: Thymic Development and Involution |
| title_full | MicroRNA Functions in Thymic Biology: Thymic Development and Involution |
| title_fullStr | MicroRNA Functions in Thymic Biology: Thymic Development and Involution |
| title_full_unstemmed | MicroRNA Functions in Thymic Biology: Thymic Development and Involution |
| title_short | MicroRNA Functions in Thymic Biology: Thymic Development and Involution |
| title_sort | microrna functions in thymic biology thymic development and involution |
| topic | microRNA thymic epithelial cells thymic development thymic involution thymic microenvironment thymus aging |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02063/full |
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