The interplay between obesity and cancer: a fly view
Accumulating epidemiological evidence indicates a strong clinical association between obesity and an increased risk of cancer. The global pandemic of obesity indicates a public health trend towards a substantial increase in cancer incidence and mortality. However, the mechanisms that link obesity to...
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| Format: | Article |
| Language: | English |
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The Company of Biologists
2016-09-01
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| Series: | Disease Models & Mechanisms |
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| Online Access: | http://dmm.biologists.org/content/9/9/917 |
| _version_ | 1818150516094402560 |
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| author | Susumu Hirabayashi |
| author_facet | Susumu Hirabayashi |
| author_sort | Susumu Hirabayashi |
| collection | DOAJ |
| description | Accumulating epidemiological evidence indicates a strong clinical association between obesity and an increased risk of cancer. The global pandemic of obesity indicates a public health trend towards a substantial increase in cancer incidence and mortality. However, the mechanisms that link obesity to cancer remain incompletely understood. The fruit fly Drosophila melanogaster has been increasingly used to model an expanding spectrum of human diseases. Fly models provide a genetically simpler system that is ideal for use as a first step towards dissecting disease interactions. Recently, the combining of fly models of diet-induced obesity with models of cancer has provided a novel model system in which to study the biological mechanisms that underlie the connections between obesity and cancer. In this Review, I summarize recent advances, made using Drosophila, in our understanding of the interplay between diet, obesity, insulin resistance and cancer. I also discuss how the biological mechanisms and therapeutic targets that have been identified in fly studies could be utilized to develop preventative interventions and treatment strategies for obesity-associated cancers. |
| first_indexed | 2024-12-11T13:24:10Z |
| format | Article |
| id | doaj.art-809598afe5cd4d6ab3eda7b869bac32a |
| institution | Directory Open Access Journal |
| issn | 1754-8403 1754-8411 |
| language | English |
| last_indexed | 2024-12-11T13:24:10Z |
| publishDate | 2016-09-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Disease Models & Mechanisms |
| spelling | doaj.art-809598afe5cd4d6ab3eda7b869bac32a2022-12-22T01:05:38ZengThe Company of BiologistsDisease Models & Mechanisms1754-84031754-84112016-09-019991792610.1242/dmm.025320025320The interplay between obesity and cancer: a fly viewSusumu Hirabayashi0 Metabolism and Cell Growth Group, MRC Clinical Sciences Centre (CSC), Du Cane Road, London W12 0NN, UK Accumulating epidemiological evidence indicates a strong clinical association between obesity and an increased risk of cancer. The global pandemic of obesity indicates a public health trend towards a substantial increase in cancer incidence and mortality. However, the mechanisms that link obesity to cancer remain incompletely understood. The fruit fly Drosophila melanogaster has been increasingly used to model an expanding spectrum of human diseases. Fly models provide a genetically simpler system that is ideal for use as a first step towards dissecting disease interactions. Recently, the combining of fly models of diet-induced obesity with models of cancer has provided a novel model system in which to study the biological mechanisms that underlie the connections between obesity and cancer. In this Review, I summarize recent advances, made using Drosophila, in our understanding of the interplay between diet, obesity, insulin resistance and cancer. I also discuss how the biological mechanisms and therapeutic targets that have been identified in fly studies could be utilized to develop preventative interventions and treatment strategies for obesity-associated cancers.http://dmm.biologists.org/content/9/9/917CancerDrosophilaObesity |
| spellingShingle | Susumu Hirabayashi The interplay between obesity and cancer: a fly view Disease Models & Mechanisms Cancer Drosophila Obesity |
| title | The interplay between obesity and cancer: a fly view |
| title_full | The interplay between obesity and cancer: a fly view |
| title_fullStr | The interplay between obesity and cancer: a fly view |
| title_full_unstemmed | The interplay between obesity and cancer: a fly view |
| title_short | The interplay between obesity and cancer: a fly view |
| title_sort | interplay between obesity and cancer a fly view |
| topic | Cancer Drosophila Obesity |
| url | http://dmm.biologists.org/content/9/9/917 |
| work_keys_str_mv | AT susumuhirabayashi theinterplaybetweenobesityandcanceraflyview AT susumuhirabayashi interplaybetweenobesityandcanceraflyview |