β-catenin-IRP2-primed iron availability to mitochondrial metabolism is druggable for active β-catenin-mediated cancer

β-catenin-IRP2-primed iron availability to mitochondrial metabolism is druggable for active β-catenin-mediated cancer

Abstract Background Although β-catenin signaling cascade is frequently altered in human cancers, targeting this pathway has not been approved for cancer treatment. Methods High-throughput screening of an FDA-approved drug library was conducted to identify therapeutics that selectively inhibited the...

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Bibliographic Details
Main Authors: Yuting Wu, Shuhui Yang, Luyang Han, Kezhuo Shang, Baohui Zhang, Xiaochen Gai, Weiwei Deng, Fangming Liu, Hongbing Zhang
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Translational Medicine
Subjects:
β-catenin
IRP2
Labile iron pool
Iron chelator
Mitochondrial function
Online Access:https://doi.org/10.1186/s12967-023-03914-0

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