β-catenin-IRP2-primed iron availability to mitochondrial metabolism is druggable for active β-catenin-mediated cancer
Abstract Background Although β-catenin signaling cascade is frequently altered in human cancers, targeting this pathway has not been approved for cancer treatment. Methods High-throughput screening of an FDA-approved drug library was conducted to identify therapeutics that selectively inhibited the...
Main Authors: | Yuting Wu, Shuhui Yang, Luyang Han, Kezhuo Shang, Baohui Zhang, Xiaochen Gai, Weiwei Deng, Fangming Liu, Hongbing Zhang |
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Format: | Article |
Language: | English |
Published: |
BMC
2023-01-01
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Series: | Journal of Translational Medicine |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12967-023-03914-0 |
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