Immune Lymphocyte Infiltrate and its Prognostic Value in Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC) occurs more frequently in young (<50 years) non-Hispanic black and Hispanic/Latina women. It is considered the most aggressive subtype of breast cancer, although, recently, immune infiltrate has been associated with long-term survival, lower risk of death...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.910976/full |
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| author | Carlos Alexander Huertas-Caro Mayra Alejandra Ramirez Henry J. Gonzalez-Torres Henry J. Gonzalez-Torres María Carolina Sanabria-Salas Silvia J. Serrano-Gómez |
| author_facet | Carlos Alexander Huertas-Caro Mayra Alejandra Ramirez Henry J. Gonzalez-Torres Henry J. Gonzalez-Torres María Carolina Sanabria-Salas Silvia J. Serrano-Gómez |
| author_sort | Carlos Alexander Huertas-Caro |
| collection | DOAJ |
| description | Triple-negative breast cancer (TNBC) occurs more frequently in young (<50 years) non-Hispanic black and Hispanic/Latina women. It is considered the most aggressive subtype of breast cancer, although, recently, immune infiltrate has been associated with long-term survival, lower risk of death and recurrence, and response to neoadjuvant chemotherapy. The aim of this review was to evaluate the clinical impact of the immune infiltrate in TNBC by discussing whether its prognostic value varies across different populations. A comprehensive systematic search in databases such as PubMed and Web of Science was conducted to include papers focused on tumor-infiltrating lymphocytes (TILs) in TNBC in different population groups and that were published before January 2021. TNBC patients with higher levels of TILs had longer overall survival and disease-free survival times compared with TNBC patients with low TIL levels. Similar results were observed for CD4+, CD8+ TIL populations. On the other hand, patients with high TIL levels showed a higher rate of pathological complete response regardless of the population group (Asian, European, and American). These results altogether suggest that TIL subpopulations might have a prognostic role in TNBC, but the underlying mechanism needs to be elucidated. Although the prognosis value of TILs was not found different between the population groups analyzed in the revised literature, further studies including underrepresented populations with different genetic ancestries are still necessary to conclude in this regard. |
| first_indexed | 2024-04-13T05:40:24Z |
| format | Article |
| id | doaj.art-809730699674440fb9e2b3dca7182447 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T05:40:24Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-809730699674440fb9e2b3dca71824472022-12-22T03:00:08ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-07-011210.3389/fonc.2022.910976910976Immune Lymphocyte Infiltrate and its Prognostic Value in Triple-Negative Breast CancerCarlos Alexander Huertas-Caro0Mayra Alejandra Ramirez1Henry J. Gonzalez-Torres2Henry J. Gonzalez-Torres3María Carolina Sanabria-Salas4Silvia J. Serrano-Gómez5Grupo de investigación en biología del cáncer, Instituto Nacional de Cancerología, Bogotá, ColombiaGrupo de investigación en biología del cáncer, Instituto Nacional de Cancerología, Bogotá, ColombiaDoctorado en Ciencias Biomédicas, Universidad del Valle, Cali, ColombiaFacultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla, ColombiaGrupo de investigación en biología del cáncer, Instituto Nacional de Cancerología, Bogotá, ColombiaGrupo de apoyo y seguimiento para la investigación, Instituto Nacional de Cancerología, Bogotá, ColombiaTriple-negative breast cancer (TNBC) occurs more frequently in young (<50 years) non-Hispanic black and Hispanic/Latina women. It is considered the most aggressive subtype of breast cancer, although, recently, immune infiltrate has been associated with long-term survival, lower risk of death and recurrence, and response to neoadjuvant chemotherapy. The aim of this review was to evaluate the clinical impact of the immune infiltrate in TNBC by discussing whether its prognostic value varies across different populations. A comprehensive systematic search in databases such as PubMed and Web of Science was conducted to include papers focused on tumor-infiltrating lymphocytes (TILs) in TNBC in different population groups and that were published before January 2021. TNBC patients with higher levels of TILs had longer overall survival and disease-free survival times compared with TNBC patients with low TIL levels. Similar results were observed for CD4+, CD8+ TIL populations. On the other hand, patients with high TIL levels showed a higher rate of pathological complete response regardless of the population group (Asian, European, and American). These results altogether suggest that TIL subpopulations might have a prognostic role in TNBC, but the underlying mechanism needs to be elucidated. Although the prognosis value of TILs was not found different between the population groups analyzed in the revised literature, further studies including underrepresented populations with different genetic ancestries are still necessary to conclude in this regard.https://www.frontiersin.org/articles/10.3389/fonc.2022.910976/fulltriple-negative breast cancertumor-infiltrating lymphocytesprognosispredictivepopulation groups |
| spellingShingle | Carlos Alexander Huertas-Caro Mayra Alejandra Ramirez Henry J. Gonzalez-Torres Henry J. Gonzalez-Torres María Carolina Sanabria-Salas Silvia J. Serrano-Gómez Immune Lymphocyte Infiltrate and its Prognostic Value in Triple-Negative Breast Cancer Frontiers in Oncology triple-negative breast cancer tumor-infiltrating lymphocytes prognosis predictive population groups |
| title | Immune Lymphocyte Infiltrate and its Prognostic Value in Triple-Negative Breast Cancer |
| title_full | Immune Lymphocyte Infiltrate and its Prognostic Value in Triple-Negative Breast Cancer |
| title_fullStr | Immune Lymphocyte Infiltrate and its Prognostic Value in Triple-Negative Breast Cancer |
| title_full_unstemmed | Immune Lymphocyte Infiltrate and its Prognostic Value in Triple-Negative Breast Cancer |
| title_short | Immune Lymphocyte Infiltrate and its Prognostic Value in Triple-Negative Breast Cancer |
| title_sort | immune lymphocyte infiltrate and its prognostic value in triple negative breast cancer |
| topic | triple-negative breast cancer tumor-infiltrating lymphocytes prognosis predictive population groups |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.910976/full |
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