Sonic Hedgehog Regulates Proliferation, Migration and Invasion of Synoviocytes in Rheumatoid Arthritis via JNK Signaling

Sonic Hedgehog Regulates Proliferation, Migration and Invasion of Synoviocytes in Rheumatoid Arthritis via JNK Signaling

Activated fibroblast-like synoviocytes (FLSs) play a central role in the formation of synovial pannus and joint destruction in rheumatoid arthritis (RA). Targeting FLSs could be a potential therapeutic strategy. The objective of this study is to explore the role of c-Jun N-terminal kinase (JNK) in p...

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Bibliographic Details
Main Authors: Shangling Zhu, Yuanmei Ye, Yiming Shi, Junlong Dang, Xiaoxue Feng, Yingdi Chen, Fang Liu, Nancy Olsen, Jianlin Huang, Song Guo Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
fibroblast-like synoviocyte
proliferation
migration
invasion
sonic hedgehog
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01300/full

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