Matrix Tablets Based on Chitosan–Carrageenan Polyelectrolyte Complex: Unique Matrices for Drug Targeting in the Intestine
The present study focused on the more detailed characterization of chitosan–carrageenan-based matrix tablets with respect to their potential utilization for drug targeting in the intestine. The study systematically dealt with the particular stages of the dissolution process, as well as with differen...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/8/980 |
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| author | Alena Komersová Roman Svoboda Barbora Skalická Martin Bartoš Eva Šnejdrová Jitka Mužíková Kevin Matzick |
| author_facet | Alena Komersová Roman Svoboda Barbora Skalická Martin Bartoš Eva Šnejdrová Jitka Mužíková Kevin Matzick |
| author_sort | Alena Komersová |
| collection | DOAJ |
| description | The present study focused on the more detailed characterization of chitosan–carrageenan-based matrix tablets with respect to their potential utilization for drug targeting in the intestine. The study systematically dealt with the particular stages of the dissolution process, as well as with different views of the physico-chemical processes involved in these stages. The initial swelling of the tablets in the acidic medium based on the combined microscopy–calorimetry point of view, the pH-induced differences in the erosion and swelling of the tested tablets, and the morphological characterization of the tablets are discussed. The dissolution kinetics correlated with the rheological properties and mucoadhesive behavior of the tablets are also reported, and, correspondingly, the formulations with suitable properties were identified. It was confirmed that the formation of the chitosan–carrageenan polyelectrolyte complex may be an elegant and beneficial alternative solution for the drug targeting to the intestine by the matrix tablet. |
| first_indexed | 2024-03-09T09:51:01Z |
| format | Article |
| id | doaj.art-809a3499b75e41eda3c8269ce761e27d |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T09:51:01Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-809a3499b75e41eda3c8269ce761e27d2023-12-02T00:08:58ZengMDPI AGPharmaceuticals1424-82472022-08-0115898010.3390/ph15080980Matrix Tablets Based on Chitosan–Carrageenan Polyelectrolyte Complex: Unique Matrices for Drug Targeting in the IntestineAlena Komersová0Roman Svoboda1Barbora Skalická2Martin Bartoš3Eva Šnejdrová4Jitka Mužíková5Kevin Matzick6Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 95, 532 10 Pardubice, Czech RepublicDepartment of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 95, 532 10 Pardubice, Czech RepublicDepartment of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 95, 532 10 Pardubice, Czech RepublicDepartment of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 95, 532 10 Pardubice, Czech RepublicDepartment of Pharmaceutical Technology, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech RepublicDepartment of Pharmaceutical Technology, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech RepublicDepartment of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 95, 532 10 Pardubice, Czech RepublicThe present study focused on the more detailed characterization of chitosan–carrageenan-based matrix tablets with respect to their potential utilization for drug targeting in the intestine. The study systematically dealt with the particular stages of the dissolution process, as well as with different views of the physico-chemical processes involved in these stages. The initial swelling of the tablets in the acidic medium based on the combined microscopy–calorimetry point of view, the pH-induced differences in the erosion and swelling of the tested tablets, and the morphological characterization of the tablets are discussed. The dissolution kinetics correlated with the rheological properties and mucoadhesive behavior of the tablets are also reported, and, correspondingly, the formulations with suitable properties were identified. It was confirmed that the formation of the chitosan–carrageenan polyelectrolyte complex may be an elegant and beneficial alternative solution for the drug targeting to the intestine by the matrix tablet.https://www.mdpi.com/1424-8247/15/8/980polyelectrolyte complexcarrageenanchitosandrug targeting |
| spellingShingle | Alena Komersová Roman Svoboda Barbora Skalická Martin Bartoš Eva Šnejdrová Jitka Mužíková Kevin Matzick Matrix Tablets Based on Chitosan–Carrageenan Polyelectrolyte Complex: Unique Matrices for Drug Targeting in the Intestine Pharmaceuticals polyelectrolyte complex carrageenan chitosan drug targeting |
| title | Matrix Tablets Based on Chitosan–Carrageenan Polyelectrolyte Complex: Unique Matrices for Drug Targeting in the Intestine |
| title_full | Matrix Tablets Based on Chitosan–Carrageenan Polyelectrolyte Complex: Unique Matrices for Drug Targeting in the Intestine |
| title_fullStr | Matrix Tablets Based on Chitosan–Carrageenan Polyelectrolyte Complex: Unique Matrices for Drug Targeting in the Intestine |
| title_full_unstemmed | Matrix Tablets Based on Chitosan–Carrageenan Polyelectrolyte Complex: Unique Matrices for Drug Targeting in the Intestine |
| title_short | Matrix Tablets Based on Chitosan–Carrageenan Polyelectrolyte Complex: Unique Matrices for Drug Targeting in the Intestine |
| title_sort | matrix tablets based on chitosan carrageenan polyelectrolyte complex unique matrices for drug targeting in the intestine |
| topic | polyelectrolyte complex carrageenan chitosan drug targeting |
| url | https://www.mdpi.com/1424-8247/15/8/980 |
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