Gut microbiome dysbiosis and correlation with blood biomarkers in active-tuberculosis in endemic setting.
Tuberculosis (TB) is the largest infectious disease with 10 million new active-TB patients and1.7 million deaths per year. Active-TB is an inflammatory disease and is increasingly viewed as an imbalance of immune responses to M. tb. infection. The mechanisms of a switch from latent infection to acti...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0245534 |
| _version_ | 1818891775045009408 |
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| author | Aasia Khaliq Resmi Ravindran Samia Afzal Prasant Kumar Jena Muhammad Waheed Akhtar Atiqa Ambreen Yu-Jui Yvonne Wan Kauser Abdulla Malik Muhammad Irfan Imran H Khan |
| author_facet | Aasia Khaliq Resmi Ravindran Samia Afzal Prasant Kumar Jena Muhammad Waheed Akhtar Atiqa Ambreen Yu-Jui Yvonne Wan Kauser Abdulla Malik Muhammad Irfan Imran H Khan |
| author_sort | Aasia Khaliq |
| collection | DOAJ |
| description | Tuberculosis (TB) is the largest infectious disease with 10 million new active-TB patients and1.7 million deaths per year. Active-TB is an inflammatory disease and is increasingly viewed as an imbalance of immune responses to M. tb. infection. The mechanisms of a switch from latent infection to active disease is not well worked out but a shift in the immune responses is thought to be responsible. Increasingly, the role of gut microbiota has been described as a major influencer of the immune system. And because the gut is the largest immune organ, we aimed to analyze the gut microbiome in active-TB patients in a TB-endemic country, Pakistan. The study revealed that Ruminococcacea, Enetrobactericeae, Erysipelotrichaceae, Bifidobacterium, etc. were the major genera associated with active-TB, also associated with chronic inflammatory disease. Plasma antibody profiles against several M. tb. antigens, as specific biomarkers for active-TB, correlated closely with the patient gut microbial profiles. Besides, bcoA gene copy number, indicative of the level of butyrate production by the gut microbiome was five-fold lower in TB patients compared to healthy individuals. These findings suggest that gut health in TB patients is compromised, with implications for disease morbidity (e.g., severe weight loss) as well as immune impairment. |
| first_indexed | 2024-12-19T17:46:10Z |
| format | Article |
| id | doaj.art-809b821baef9489daa59dd791c08fe16 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T17:46:10Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-809b821baef9489daa59dd791c08fe162022-12-21T20:12:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01161e024553410.1371/journal.pone.0245534Gut microbiome dysbiosis and correlation with blood biomarkers in active-tuberculosis in endemic setting.Aasia KhaliqResmi RavindranSamia AfzalPrasant Kumar JenaMuhammad Waheed AkhtarAtiqa AmbreenYu-Jui Yvonne WanKauser Abdulla MalikMuhammad IrfanImran H KhanTuberculosis (TB) is the largest infectious disease with 10 million new active-TB patients and1.7 million deaths per year. Active-TB is an inflammatory disease and is increasingly viewed as an imbalance of immune responses to M. tb. infection. The mechanisms of a switch from latent infection to active disease is not well worked out but a shift in the immune responses is thought to be responsible. Increasingly, the role of gut microbiota has been described as a major influencer of the immune system. And because the gut is the largest immune organ, we aimed to analyze the gut microbiome in active-TB patients in a TB-endemic country, Pakistan. The study revealed that Ruminococcacea, Enetrobactericeae, Erysipelotrichaceae, Bifidobacterium, etc. were the major genera associated with active-TB, also associated with chronic inflammatory disease. Plasma antibody profiles against several M. tb. antigens, as specific biomarkers for active-TB, correlated closely with the patient gut microbial profiles. Besides, bcoA gene copy number, indicative of the level of butyrate production by the gut microbiome was five-fold lower in TB patients compared to healthy individuals. These findings suggest that gut health in TB patients is compromised, with implications for disease morbidity (e.g., severe weight loss) as well as immune impairment.https://doi.org/10.1371/journal.pone.0245534 |
| spellingShingle | Aasia Khaliq Resmi Ravindran Samia Afzal Prasant Kumar Jena Muhammad Waheed Akhtar Atiqa Ambreen Yu-Jui Yvonne Wan Kauser Abdulla Malik Muhammad Irfan Imran H Khan Gut microbiome dysbiosis and correlation with blood biomarkers in active-tuberculosis in endemic setting. PLoS ONE |
| title | Gut microbiome dysbiosis and correlation with blood biomarkers in active-tuberculosis in endemic setting. |
| title_full | Gut microbiome dysbiosis and correlation with blood biomarkers in active-tuberculosis in endemic setting. |
| title_fullStr | Gut microbiome dysbiosis and correlation with blood biomarkers in active-tuberculosis in endemic setting. |
| title_full_unstemmed | Gut microbiome dysbiosis and correlation with blood biomarkers in active-tuberculosis in endemic setting. |
| title_short | Gut microbiome dysbiosis and correlation with blood biomarkers in active-tuberculosis in endemic setting. |
| title_sort | gut microbiome dysbiosis and correlation with blood biomarkers in active tuberculosis in endemic setting |
| url | https://doi.org/10.1371/journal.pone.0245534 |
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