Anti-Obesity Effects of <i>Sargassum thunbergii</i> via Downregulation of Adipogenesis Gene and Upregulation of Thermogenic Genes in High-Fat Diet-Induced Obese Mice
Obesity is a metabolic disease characterized by an increased risk of type 2 diabetes, hypertension, and cardiovascular disease. We have previously reported that compounds isolated from brown alga, <i>Sargassum thunbergii</i> (ST; <i>Sargassum thunbergii</i> (Mertens ex Roth)...
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MDPI AG
2020-10-01
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| author | Min-Cheol Kang Hyo-Geun Lee Hyun-Soo Kim Kyung-Mo Song Yong-Gi Chun Min Hyeock Lee Bum-Keun Kim You-Jin Jeon |
| author_facet | Min-Cheol Kang Hyo-Geun Lee Hyun-Soo Kim Kyung-Mo Song Yong-Gi Chun Min Hyeock Lee Bum-Keun Kim You-Jin Jeon |
| author_sort | Min-Cheol Kang |
| collection | DOAJ |
| description | Obesity is a metabolic disease characterized by an increased risk of type 2 diabetes, hypertension, and cardiovascular disease. We have previously reported that compounds isolated from brown alga, <i>Sargassum thunbergii</i> (ST; <i>Sargassum thunbergii</i> (Mertens ex Roth) Kuntze), inhibit adipogenesis in 3T3-L1 cells. However, the in vivo anti-obesity effects of these compounds have not been previously reported. Therefore, the objective of this study was to determine the effects of ST on weight loss, fat accumulation, as well as risk factors for type 2 diabetes and cardiovascular disease in high-fat diet (HFD)-induced obese mice. ST treatment significantly decreased body weight and fat accumulation in HFD-induced obese mice, while reducing insulin and factors related to cardiovascular diseases (triglyceride and total cholesterol) in serum. ST-induced downregulation of PPARγ in white adipose tissue, and upregulation of the thermogenic genes, <i>UCP-1</i> and <i>UCP-3</i>, in brown adipose tissue was also observed. In addition, oral administration of ST reduced the occurrence of fatty liver, as well as the amount of white adipose tissue in HFD mice. Cumulatively, these results suggest that ST exerts anti-obesity effects and may serve as a potential anti-obesity therapeutic agent. |
| first_indexed | 2024-03-10T15:14:54Z |
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| id | doaj.art-809e8737e4684244a8d8171a101752d5 |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T15:14:54Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-809e8737e4684244a8d8171a101752d52023-11-20T19:00:18ZengMDPI AGNutrients2072-66432020-10-011211332510.3390/nu12113325Anti-Obesity Effects of <i>Sargassum thunbergii</i> via Downregulation of Adipogenesis Gene and Upregulation of Thermogenic Genes in High-Fat Diet-Induced Obese MiceMin-Cheol Kang0Hyo-Geun Lee1Hyun-Soo Kim2Kyung-Mo Song3Yong-Gi Chun4Min Hyeock Lee5Bum-Keun Kim6You-Jin Jeon7Research Group of Process Engineering, Korea Food Research Institute, Jeollabuk-do 55365, KoreaDepartment of Marine Life Science, Jeju National University, Jeju 63243, KoreaDepartment of Genetic Resources Research, National Marine Biodiversity Institute of Korea, Janghang-eup 33662, KoreaResearch Group of Process Engineering, Korea Food Research Institute, Jeollabuk-do 55365, KoreaResearch Group of Process Engineering, Korea Food Research Institute, Jeollabuk-do 55365, KoreaResearch Group of Process Engineering, Korea Food Research Institute, Jeollabuk-do 55365, KoreaResearch Group of Process Engineering, Korea Food Research Institute, Jeollabuk-do 55365, KoreaDepartment of Marine Life Science, Jeju National University, Jeju 63243, KoreaObesity is a metabolic disease characterized by an increased risk of type 2 diabetes, hypertension, and cardiovascular disease. We have previously reported that compounds isolated from brown alga, <i>Sargassum thunbergii</i> (ST; <i>Sargassum thunbergii</i> (Mertens ex Roth) Kuntze), inhibit adipogenesis in 3T3-L1 cells. However, the in vivo anti-obesity effects of these compounds have not been previously reported. Therefore, the objective of this study was to determine the effects of ST on weight loss, fat accumulation, as well as risk factors for type 2 diabetes and cardiovascular disease in high-fat diet (HFD)-induced obese mice. ST treatment significantly decreased body weight and fat accumulation in HFD-induced obese mice, while reducing insulin and factors related to cardiovascular diseases (triglyceride and total cholesterol) in serum. ST-induced downregulation of PPARγ in white adipose tissue, and upregulation of the thermogenic genes, <i>UCP-1</i> and <i>UCP-3</i>, in brown adipose tissue was also observed. In addition, oral administration of ST reduced the occurrence of fatty liver, as well as the amount of white adipose tissue in HFD mice. Cumulatively, these results suggest that ST exerts anti-obesity effects and may serve as a potential anti-obesity therapeutic agent.https://www.mdpi.com/2072-6643/12/11/3325anti-obesity<i>Sargassum thunbergia</i>seaweedhigh-fat diet |
| spellingShingle | Min-Cheol Kang Hyo-Geun Lee Hyun-Soo Kim Kyung-Mo Song Yong-Gi Chun Min Hyeock Lee Bum-Keun Kim You-Jin Jeon Anti-Obesity Effects of <i>Sargassum thunbergii</i> via Downregulation of Adipogenesis Gene and Upregulation of Thermogenic Genes in High-Fat Diet-Induced Obese Mice Nutrients anti-obesity <i>Sargassum thunbergia</i> seaweed high-fat diet |
| title | Anti-Obesity Effects of <i>Sargassum thunbergii</i> via Downregulation of Adipogenesis Gene and Upregulation of Thermogenic Genes in High-Fat Diet-Induced Obese Mice |
| title_full | Anti-Obesity Effects of <i>Sargassum thunbergii</i> via Downregulation of Adipogenesis Gene and Upregulation of Thermogenic Genes in High-Fat Diet-Induced Obese Mice |
| title_fullStr | Anti-Obesity Effects of <i>Sargassum thunbergii</i> via Downregulation of Adipogenesis Gene and Upregulation of Thermogenic Genes in High-Fat Diet-Induced Obese Mice |
| title_full_unstemmed | Anti-Obesity Effects of <i>Sargassum thunbergii</i> via Downregulation of Adipogenesis Gene and Upregulation of Thermogenic Genes in High-Fat Diet-Induced Obese Mice |
| title_short | Anti-Obesity Effects of <i>Sargassum thunbergii</i> via Downregulation of Adipogenesis Gene and Upregulation of Thermogenic Genes in High-Fat Diet-Induced Obese Mice |
| title_sort | anti obesity effects of i sargassum thunbergii i via downregulation of adipogenesis gene and upregulation of thermogenic genes in high fat diet induced obese mice |
| topic | anti-obesity <i>Sargassum thunbergia</i> seaweed high-fat diet |
| url | https://www.mdpi.com/2072-6643/12/11/3325 |
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