Cardiovascular Imaging: What Have We Learned From Animal Models?
Cardiovascular imaging has become an indispensable tool for patient diagnosis and follow up. Probably the wide clinical applications of imaging are due to the possibility of a detailed and high quality description and quantification of cardiovascular system structure and function. Also phenomena tha...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-10-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00227/full |
| _version_ | 1818721129821372416 |
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| author | Arnoldo eSantos Arnoldo eSantos Arnoldo eSantos Arnoldo eSantos Leticia eFernández-Friera Leticia eFernández-Friera Maria eVillalba Beatriz eLópez-Melgar Beatriz eLópez-Melgar Samuel eEspaña Samuel eEspaña Samuel eEspaña Jesús eMateo Jesús eMateo Ruben A Mota Ruben A Mota Jesús eJiménez-Borreguero Jesús eJiménez-Borreguero Jesús eRuiz-Cabello Jesús eRuiz-Cabello Jesús eRuiz-Cabello |
| author_facet | Arnoldo eSantos Arnoldo eSantos Arnoldo eSantos Arnoldo eSantos Leticia eFernández-Friera Leticia eFernández-Friera Maria eVillalba Beatriz eLópez-Melgar Beatriz eLópez-Melgar Samuel eEspaña Samuel eEspaña Samuel eEspaña Jesús eMateo Jesús eMateo Ruben A Mota Ruben A Mota Jesús eJiménez-Borreguero Jesús eJiménez-Borreguero Jesús eRuiz-Cabello Jesús eRuiz-Cabello Jesús eRuiz-Cabello |
| author_sort | Arnoldo eSantos |
| collection | DOAJ |
| description | Cardiovascular imaging has become an indispensable tool for patient diagnosis and follow up. Probably the wide clinical applications of imaging are due to the possibility of a detailed and high quality description and quantification of cardiovascular system structure and function. Also phenomena that involve complex physiological mechanisms and biochemical pathways, such as inflammation and ischemia, can be visualized in a nondestructive way. The widespread use and evolution of imaging would not have been possible without animal studies. Animal models have allowed for instance, i) the technical development of different imaging tools, ii) to test hypothesis generated from human studies and finally, iii) to evaluate the translational relevance assessment of in vitro and ex-vivo results. In this review, we will critically describe the contribution of animal models to the use of biomedical imaging in cardiovascular medicine. We will discuss the characteristics of the most frequent models used in/for imaging studies. We will cover the major findings of animal studies focused in the cardiovascular use of the repeatedly used imaging techniques in clinical practice and experimental studies. We will also describe the physiological findings and/or learning processes for imaging applications coming from models of the most common cardiovascular diseases. In these diseases, imaging research using animals has allowed the study of aspects such as: ventricular size, shape, global function and wall thickening, local myocardial function, myocardial perfusion, metabolism and energetic assessment, infarct quantification, vascular lesion characterization, myocardial fiber structure, and myocardial calcium uptake. Finally we will discuss the limitations and future of imaging research with animal models. |
| first_indexed | 2024-12-17T20:33:50Z |
| format | Article |
| id | doaj.art-80a07dd8071441a2a7f72a6414a6bdf6 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-17T20:33:50Z |
| publishDate | 2015-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-80a07dd8071441a2a7f72a6414a6bdf62022-12-21T21:33:30ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122015-10-01610.3389/fphar.2015.00227158762Cardiovascular Imaging: What Have We Learned From Animal Models?Arnoldo eSantos0Arnoldo eSantos1Arnoldo eSantos2Arnoldo eSantos3Leticia eFernández-Friera4Leticia eFernández-Friera5Maria eVillalba6Beatriz eLópez-Melgar7Beatriz eLópez-Melgar8Samuel eEspaña9Samuel eEspaña10Samuel eEspaña11Jesús eMateo12Jesús eMateo13Ruben A Mota14Ruben A Mota15Jesús eJiménez-Borreguero16Jesús eJiménez-Borreguero17Jesús eRuiz-Cabello18Jesús eRuiz-Cabello19Jesús eRuiz-Cabello20Centro Nacional de Investigaciones Cardiovasculares (CNIC)Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, CIBERESMadrid-MIT M+Visión ConsortiumMassachusetts General Hospital and Harvard Medical SchoolCentro Nacional de Investigaciones Cardiovasculares (CNIC)Hospital Universitario HM MonteprincipeCentro Nacional de Investigaciones Cardiovasculares (CNIC)Centro Nacional de Investigaciones Cardiovasculares (CNIC)Hospital Universitario HM MonteprincipeCentro Nacional de Investigaciones Cardiovasculares (CNIC)Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, CIBERESMadrid-MIT M+Visión ConsortiumCentro Nacional de Investigaciones Cardiovasculares (CNIC)Hospital Universitario HM MonteprincipeCentro Nacional de Investigaciones Cardiovasculares (CNIC)Charles RiverCentro Nacional de Investigaciones Cardiovasculares (CNIC)Hospital de La PrincesaCentro Nacional de Investigaciones Cardiovasculares (CNIC)Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, CIBERESUniversidad Complutense de MadridCardiovascular imaging has become an indispensable tool for patient diagnosis and follow up. Probably the wide clinical applications of imaging are due to the possibility of a detailed and high quality description and quantification of cardiovascular system structure and function. Also phenomena that involve complex physiological mechanisms and biochemical pathways, such as inflammation and ischemia, can be visualized in a nondestructive way. The widespread use and evolution of imaging would not have been possible without animal studies. Animal models have allowed for instance, i) the technical development of different imaging tools, ii) to test hypothesis generated from human studies and finally, iii) to evaluate the translational relevance assessment of in vitro and ex-vivo results. In this review, we will critically describe the contribution of animal models to the use of biomedical imaging in cardiovascular medicine. We will discuss the characteristics of the most frequent models used in/for imaging studies. We will cover the major findings of animal studies focused in the cardiovascular use of the repeatedly used imaging techniques in clinical practice and experimental studies. We will also describe the physiological findings and/or learning processes for imaging applications coming from models of the most common cardiovascular diseases. In these diseases, imaging research using animals has allowed the study of aspects such as: ventricular size, shape, global function and wall thickening, local myocardial function, myocardial perfusion, metabolism and energetic assessment, infarct quantification, vascular lesion characterization, myocardial fiber structure, and myocardial calcium uptake. Finally we will discuss the limitations and future of imaging research with animal models.http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00227/fullAtherosclerosisHeart FailureMyocardial InfarctionAnimal ModelsBiomedical Imagingpulmonary hypertension |
| spellingShingle | Arnoldo eSantos Arnoldo eSantos Arnoldo eSantos Arnoldo eSantos Leticia eFernández-Friera Leticia eFernández-Friera Maria eVillalba Beatriz eLópez-Melgar Beatriz eLópez-Melgar Samuel eEspaña Samuel eEspaña Samuel eEspaña Jesús eMateo Jesús eMateo Ruben A Mota Ruben A Mota Jesús eJiménez-Borreguero Jesús eJiménez-Borreguero Jesús eRuiz-Cabello Jesús eRuiz-Cabello Jesús eRuiz-Cabello Cardiovascular Imaging: What Have We Learned From Animal Models? Frontiers in Pharmacology Atherosclerosis Heart Failure Myocardial Infarction Animal Models Biomedical Imaging pulmonary hypertension |
| title | Cardiovascular Imaging: What Have We Learned From Animal Models? |
| title_full | Cardiovascular Imaging: What Have We Learned From Animal Models? |
| title_fullStr | Cardiovascular Imaging: What Have We Learned From Animal Models? |
| title_full_unstemmed | Cardiovascular Imaging: What Have We Learned From Animal Models? |
| title_short | Cardiovascular Imaging: What Have We Learned From Animal Models? |
| title_sort | cardiovascular imaging what have we learned from animal models |
| topic | Atherosclerosis Heart Failure Myocardial Infarction Animal Models Biomedical Imaging pulmonary hypertension |
| url | http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00227/full |
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