IN VITRO SUSCEPTIBILITY OF MRSA CLINICAL ISOLATES TO CEFTAROLINE
Objective: To determine the in vitro susceptibility of MRSA clinical isolates to ceftaroline, using interpretation of zones of inhibition by disk diffusion method. Study Design: Descriptive cross sectional. Place and Duration of Study: The study was carried out at the Department of Microbiology, C...
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2018-04-01
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| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://www.pafmj.org/index.php/PAFMJ/article/view/463/353 |
| _version_ | 1818999993236717568 |
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| author | Muhammad Aurangzeb Raja Kamran Afzal Muhammad Abid Aamir Hussain Fauzia Aitazaz Rozina Khaliq |
| author_facet | Muhammad Aurangzeb Raja Kamran Afzal Muhammad Abid Aamir Hussain Fauzia Aitazaz Rozina Khaliq |
| author_sort | Muhammad Aurangzeb |
| collection | DOAJ |
| description | Objective: To determine the in vitro susceptibility of MRSA clinical isolates to ceftaroline, using interpretation of zones of inhibition by disk diffusion method.
Study Design: Descriptive cross sectional.
Place and Duration of Study: The study was carried out at the Department of Microbiology, Combined Military Hospital Peshawar, from Jan to Dec 2014.
Material and Methods: To carry out this descriptive cross sectional study, clinical specimens were obtained from indoor and outdoor patients of Combined Military Hospital Peshawar. All the isolates of MRSA cultured with CLSI guidelines and identified with standard microbiological procedures, from clinical specimens of pus, body fluid, urine, tissue and blood were included in the study. The antimicrobial susceptibility pattern of ceftaroline was determined according to CLSI guidelines. The data was analyzed in SPSS (version 19) software.
Results: Out of a total 190 MRSA isolates, 183 (96.3%) were susceptible to ceftaroline in vitro, whereas 5 (2.6%)were resistant and 2 (1.1%) were intermediate in their response to ceftaroline.
Conclusion: Ceftaroline can be used effectively against infections caused by MRSA as it has shown very high in vitro activity against MRSA strains of clinical origin. |
| first_indexed | 2024-12-20T22:26:15Z |
| format | Article |
| id | doaj.art-80a1bf2bb8be4421beecb2c24d111031 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-12-20T22:26:15Z |
| publishDate | 2018-04-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-80a1bf2bb8be4421beecb2c24d1110312022-12-21T19:24:49ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422018-04-01682265268IN VITRO SUSCEPTIBILITY OF MRSA CLINICAL ISOLATES TO CEFTAROLINEMuhammad Aurangzeb0Raja Kamran Afzal1Muhammad Abid2Aamir Hussain3Fauzia Aitazaz4Rozina Khaliq572 Medical Battalion Pano Aqil Sindh PakistanCombined Military Hospital Peshawar PakistanCombined Military Hospital Peshawar Pakistan,Combined Military Hospital Peshawar PakistanAzad Jammu Kashmir Medical College Muzaffarabad PakistanCombined Military Hospital Peshawar PakistanObjective: To determine the in vitro susceptibility of MRSA clinical isolates to ceftaroline, using interpretation of zones of inhibition by disk diffusion method. Study Design: Descriptive cross sectional. Place and Duration of Study: The study was carried out at the Department of Microbiology, Combined Military Hospital Peshawar, from Jan to Dec 2014. Material and Methods: To carry out this descriptive cross sectional study, clinical specimens were obtained from indoor and outdoor patients of Combined Military Hospital Peshawar. All the isolates of MRSA cultured with CLSI guidelines and identified with standard microbiological procedures, from clinical specimens of pus, body fluid, urine, tissue and blood were included in the study. The antimicrobial susceptibility pattern of ceftaroline was determined according to CLSI guidelines. The data was analyzed in SPSS (version 19) software. Results: Out of a total 190 MRSA isolates, 183 (96.3%) were susceptible to ceftaroline in vitro, whereas 5 (2.6%)were resistant and 2 (1.1%) were intermediate in their response to ceftaroline. Conclusion: Ceftaroline can be used effectively against infections caused by MRSA as it has shown very high in vitro activity against MRSA strains of clinical origin.https://www.pafmj.org/index.php/PAFMJ/article/view/463/353antimicrobial susceptibilityceftarolinemrsa |
| spellingShingle | Muhammad Aurangzeb Raja Kamran Afzal Muhammad Abid Aamir Hussain Fauzia Aitazaz Rozina Khaliq IN VITRO SUSCEPTIBILITY OF MRSA CLINICAL ISOLATES TO CEFTAROLINE Pakistan Armed Forces Medical Journal antimicrobial susceptibility ceftaroline mrsa |
| title | IN VITRO SUSCEPTIBILITY OF MRSA CLINICAL ISOLATES TO CEFTAROLINE |
| title_full | IN VITRO SUSCEPTIBILITY OF MRSA CLINICAL ISOLATES TO CEFTAROLINE |
| title_fullStr | IN VITRO SUSCEPTIBILITY OF MRSA CLINICAL ISOLATES TO CEFTAROLINE |
| title_full_unstemmed | IN VITRO SUSCEPTIBILITY OF MRSA CLINICAL ISOLATES TO CEFTAROLINE |
| title_short | IN VITRO SUSCEPTIBILITY OF MRSA CLINICAL ISOLATES TO CEFTAROLINE |
| title_sort | in vitro susceptibility of mrsa clinical isolates to ceftaroline |
| topic | antimicrobial susceptibility ceftaroline mrsa |
| url | https://www.pafmj.org/index.php/PAFMJ/article/view/463/353 |
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