Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues

Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues

Summary: Cardiac in vitro models have become increasingly obtainable and affordable with the optimization of human pluripotent stem cell-derived cardiomyocyte (hPSC-CM) differentiation. However, these CMs are immature compared to their in vivo counterparts. Here we study the cellular phenotype of hP...

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Bibliographic Details
Main Authors:	Shangli Cheng, David Brenière-Letuffe, Virpi Ahola, Andy O.T. Wong, Hoi Yee Keung, Bimal Gurung, Zongli Zheng, Kevin D. Costa, Deborah K. Lieu, Wendy Keung, Ronald A. Li
Format:	Article
Language:	English
Published:	Elsevier 2023-04-01
Series:	iScience
Subjects:	Cell biology Stem cells research Tissue Engineering
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004223003796

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