| Summary: | A series of new acetamide derivatives <b>22</b>–<b>28</b> of primary and secondary amines and <i>para</i>-toluene sulphinate sodium salt have been synthesized under microwave irradiation and assessed in vitro for their antibacterial activity against one Gram-positive and two Gram-negative bacterial species such as <i>S. pyogenes</i>, <i>E. coli</i>, and <i>P. mirabilis</i> using the Mueller-Hinton Agar diffusion (well diffusion) method. The synthesized compounds with significant differences in inhibition diameters and MICs were compared with those of amoxicillin, ampicillin, cephalothin, azithromycin and doxycycline. All of the evaluated acetamide derivatives were used with varying inhibition concentrations of 6.25, 12.5, 37.5, 62.5, 87.5, 112.5 and 125 µg/mL. The results show that the most important antibacterial properties were displayed by the synthetic compounds <b>22</b> and <b>24</b>, both of bear a <i>para</i>-chlorophenyl moiety incorporated into the 2-position moiety of acetamide <b>1</b>. The molecular structures of the new compounds were determined using the FT-IR and <sup>1</sup>H-NMR techniques.
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