Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients
Abstract Background Many antiseizure medications (ASMs) control seizures by blocking voltage-dependent sodium channels. Polymorphisms of sodium channel genes may affect the response to ASMs due to altering the effect of ASMs on blocking sodium channels. Methods We conducted a retrospective study of...
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| Format: | Article |
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BMC
2021-09-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-021-02395-2 |
| _version_ | 1819067625041297408 |
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| author | Chih-Hsiang Lin Chen-Jui Ho Yan-Ting Lu Meng-Han Tsai |
| author_facet | Chih-Hsiang Lin Chen-Jui Ho Yan-Ting Lu Meng-Han Tsai |
| author_sort | Chih-Hsiang Lin |
| collection | DOAJ |
| description | Abstract Background Many antiseizure medications (ASMs) control seizures by blocking voltage-dependent sodium channels. Polymorphisms of sodium channel genes may affect the response to ASMs due to altering the effect of ASMs on blocking sodium channels. Methods We conducted a retrospective study of epilepsy patients followed up at the Neurological Department of Kaohsiung Chang Gung Memorial Hospital, Taiwan between January 2010 and December 2018. We categorized the patients into response, partial response, and failure to sodium channel blocking ASM groups. Sodium channel blocking ASMs included phenytoin, carbamazepine, lamotrigine, oxcarbazepine, lacosamide, zonisamide, topiramate, and valproic acid. A subgroup of predominant sodium channel blocking ASMs included phenytoin, carbamazepine, lamotrigine, oxcarbazepine, and lacosamide. Associations between the response of ASMs and single-nucleotide polymorphisms of SCN1A, SCN1B, SCN2A, and SCN9A were analyzed. Results Two hundred Taiwanese patients and 21 single-nucleotide polymorphisms among SCN1A, SCN1B, SCN2A, and SCN9A were evaluated. We found allele C of rs55742440 in SCN1B was statistically significantly associated with not achieving seizure-free with sodium channel blocking ASMs. For the predominant sodium channel blocking ASMs group, no SNPs were associated with the response of ASMs. Conclusion Single-nucleotide polymorphism in SCN1B was associated with the response to sodium channel blocking ASMs. This highlights the possibility that beta subunits may affect the function of sodium channels and resulted in different responsiveness to ASMs. |
| first_indexed | 2024-12-21T16:21:13Z |
| format | Article |
| id | doaj.art-80a6056fa73941eebe713a07afef64ac |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-21T16:21:13Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-80a6056fa73941eebe713a07afef64ac2022-12-21T18:57:34ZengBMCBMC Neurology1471-23772021-09-0121111310.1186/s12883-021-02395-2Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patientsChih-Hsiang Lin0Chen-Jui Ho1Yan-Ting Lu2Meng-Han Tsai3Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Colleague of Medicine, Chang Gung UniversityDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital, Colleague of Medicine, Chang Gung UniversityDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital, Colleague of Medicine, Chang Gung UniversityDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital, Colleague of Medicine, Chang Gung UniversityAbstract Background Many antiseizure medications (ASMs) control seizures by blocking voltage-dependent sodium channels. Polymorphisms of sodium channel genes may affect the response to ASMs due to altering the effect of ASMs on blocking sodium channels. Methods We conducted a retrospective study of epilepsy patients followed up at the Neurological Department of Kaohsiung Chang Gung Memorial Hospital, Taiwan between January 2010 and December 2018. We categorized the patients into response, partial response, and failure to sodium channel blocking ASM groups. Sodium channel blocking ASMs included phenytoin, carbamazepine, lamotrigine, oxcarbazepine, lacosamide, zonisamide, topiramate, and valproic acid. A subgroup of predominant sodium channel blocking ASMs included phenytoin, carbamazepine, lamotrigine, oxcarbazepine, and lacosamide. Associations between the response of ASMs and single-nucleotide polymorphisms of SCN1A, SCN1B, SCN2A, and SCN9A were analyzed. Results Two hundred Taiwanese patients and 21 single-nucleotide polymorphisms among SCN1A, SCN1B, SCN2A, and SCN9A were evaluated. We found allele C of rs55742440 in SCN1B was statistically significantly associated with not achieving seizure-free with sodium channel blocking ASMs. For the predominant sodium channel blocking ASMs group, no SNPs were associated with the response of ASMs. Conclusion Single-nucleotide polymorphism in SCN1B was associated with the response to sodium channel blocking ASMs. This highlights the possibility that beta subunits may affect the function of sodium channels and resulted in different responsiveness to ASMs.https://doi.org/10.1186/s12883-021-02395-2Antiseizure medicationsSodium channel geneSingle-nucleotide polymorphismsDrug resistance epilepsySCN1B |
| spellingShingle | Chih-Hsiang Lin Chen-Jui Ho Yan-Ting Lu Meng-Han Tsai Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients BMC Neurology Antiseizure medications Sodium channel gene Single-nucleotide polymorphisms Drug resistance epilepsy SCN1B |
| title | Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients |
| title_full | Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients |
| title_fullStr | Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients |
| title_full_unstemmed | Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients |
| title_short | Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients |
| title_sort | response to sodium channel blocking antiseizure medications and coding polymorphisms of sodium channel genes in taiwanese epilepsy patients |
| topic | Antiseizure medications Sodium channel gene Single-nucleotide polymorphisms Drug resistance epilepsy SCN1B |
| url | https://doi.org/10.1186/s12883-021-02395-2 |
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