Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients

Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients

Abstract Background Many antiseizure medications (ASMs) control seizures by blocking voltage-dependent sodium channels. Polymorphisms of sodium channel genes may affect the response to ASMs due to altering the effect of ASMs on blocking sodium channels. Methods We conducted a retrospective study of...

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Bibliographic Details
Main Authors: Chih-Hsiang Lin, Chen-Jui Ho, Yan-Ting Lu, Meng-Han Tsai
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Neurology
Subjects:
Antiseizure medications
Sodium channel gene
Single-nucleotide polymorphisms
Drug resistance epilepsy
SCN1B
Online Access:https://doi.org/10.1186/s12883-021-02395-2

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