Mechanochemical Effect on Controlled Drug Release of Konjac Glucomannan Matrix Tablets during Dry Grinding
To design a controlled drug release preparation based on a safe natural material, a Konjac glucomannan (KGM) mixture containing 16.0 <i>w/w</i>% calcium hydroxide (Ca(OH)<sub>2</sub>) was ground in a planetary ball mill for 0–120 min. The mechanochemical effect on the physico...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/8/3/181 |
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| author | Fuminori Okazaki Yusuke Hattori Tetsuo Sasaki Makoto Otsuka |
| author_facet | Fuminori Okazaki Yusuke Hattori Tetsuo Sasaki Makoto Otsuka |
| author_sort | Fuminori Okazaki |
| collection | DOAJ |
| description | To design a controlled drug release preparation based on a safe natural material, a Konjac glucomannan (KGM) mixture containing 16.0 <i>w/w</i>% calcium hydroxide (Ca(OH)<sub>2</sub>) was ground in a planetary ball mill for 0–120 min. The mechanochemical effect on the physicochemical properties of the KGM ground product was investigated by Fourier-transform infrared spectroscopy (FT-IR), powder X-ray spectroscopy, scanning electron microscopy with energy-dispersive X-ray spectroscopy, and drug release testing. The FT-IR spectra of the ground KGM indicated that the deacetylation reaction of KGM was accelerated in the Ca(OH)<sub>2</sub>-containing sols by mechanochemical energy, and the degree of deacetylation of KGM was dependent on the grinding time. The time required for tablet disintegration of the KGM matrix tablets containing theophylline increased as the grinding time increased; therefore, drug release was sustained. The Higuchi plots of the matrix tablets obtained from KGM ground for 60–120 min exhibited good linearity because they maintained their gel matrix tablet shape during the release test. However, KGM tablets ground for 0–30 min exhibited nonlinear curves, which were caused by tablet disintegration. This suggests that drug release from the KGM matrix tablet can be freely controlled by the degree of mechanochemical treatment. |
| first_indexed | 2024-03-09T19:48:24Z |
| format | Article |
| id | doaj.art-80a7ce7e49db4b308478aa9f4de19c8f |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T19:48:24Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-80a7ce7e49db4b308478aa9f4de19c8f2023-11-24T01:16:53ZengMDPI AGGels2310-28612022-03-018318110.3390/gels8030181Mechanochemical Effect on Controlled Drug Release of Konjac Glucomannan Matrix Tablets during Dry GrindingFuminori Okazaki0Yusuke Hattori1Tetsuo Sasaki2Makoto Otsuka3Faculty of Pharmacy, Musashino University, 1-1-20 Shinmachi, Nishi-Tokyo 202-8585, Tokyo, JapanFaculty of Pharmacy, Musashino University, 1-1-20 Shinmachi, Nishi-Tokyo 202-8585, Tokyo, JapanGraduate School of Medical Photonics, Shizuoka University, 3-5-1 Johoku, Naka-ku, Hamamatsu 432-8011, Shizuoka, JapanFaculty of Pharmacy, Musashino University, 1-1-20 Shinmachi, Nishi-Tokyo 202-8585, Tokyo, JapanTo design a controlled drug release preparation based on a safe natural material, a Konjac glucomannan (KGM) mixture containing 16.0 <i>w/w</i>% calcium hydroxide (Ca(OH)<sub>2</sub>) was ground in a planetary ball mill for 0–120 min. The mechanochemical effect on the physicochemical properties of the KGM ground product was investigated by Fourier-transform infrared spectroscopy (FT-IR), powder X-ray spectroscopy, scanning electron microscopy with energy-dispersive X-ray spectroscopy, and drug release testing. The FT-IR spectra of the ground KGM indicated that the deacetylation reaction of KGM was accelerated in the Ca(OH)<sub>2</sub>-containing sols by mechanochemical energy, and the degree of deacetylation of KGM was dependent on the grinding time. The time required for tablet disintegration of the KGM matrix tablets containing theophylline increased as the grinding time increased; therefore, drug release was sustained. The Higuchi plots of the matrix tablets obtained from KGM ground for 60–120 min exhibited good linearity because they maintained their gel matrix tablet shape during the release test. However, KGM tablets ground for 0–30 min exhibited nonlinear curves, which were caused by tablet disintegration. This suggests that drug release from the KGM matrix tablet can be freely controlled by the degree of mechanochemical treatment.https://www.mdpi.com/2310-2861/8/3/181konjac glucomannansolid-state mechanochemical reactionswelling and disintegration propertyFourier-transform infrared spectral changepolymer matrix tabletssustained drug release kinetics |
| spellingShingle | Fuminori Okazaki Yusuke Hattori Tetsuo Sasaki Makoto Otsuka Mechanochemical Effect on Controlled Drug Release of Konjac Glucomannan Matrix Tablets during Dry Grinding Gels konjac glucomannan solid-state mechanochemical reaction swelling and disintegration property Fourier-transform infrared spectral change polymer matrix tablets sustained drug release kinetics |
| title | Mechanochemical Effect on Controlled Drug Release of Konjac Glucomannan Matrix Tablets during Dry Grinding |
| title_full | Mechanochemical Effect on Controlled Drug Release of Konjac Glucomannan Matrix Tablets during Dry Grinding |
| title_fullStr | Mechanochemical Effect on Controlled Drug Release of Konjac Glucomannan Matrix Tablets during Dry Grinding |
| title_full_unstemmed | Mechanochemical Effect on Controlled Drug Release of Konjac Glucomannan Matrix Tablets during Dry Grinding |
| title_short | Mechanochemical Effect on Controlled Drug Release of Konjac Glucomannan Matrix Tablets during Dry Grinding |
| title_sort | mechanochemical effect on controlled drug release of konjac glucomannan matrix tablets during dry grinding |
| topic | konjac glucomannan solid-state mechanochemical reaction swelling and disintegration property Fourier-transform infrared spectral change polymer matrix tablets sustained drug release kinetics |
| url | https://www.mdpi.com/2310-2861/8/3/181 |
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