Mechanochemical Effect on Controlled Drug Release of Konjac Glucomannan Matrix Tablets during Dry Grinding

Mechanochemical Effect on Controlled Drug Release of Konjac Glucomannan Matrix Tablets during Dry Grinding

To design a controlled drug release preparation based on a safe natural material, a Konjac glucomannan (KGM) mixture containing 16.0 <i>w/w</i>% calcium hydroxide (Ca(OH)<sub>2</sub>) was ground in a planetary ball mill for 0–120 min. The mechanochemical effect on the physico...

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Bibliographic Details
Main Authors: Fuminori Okazaki, Yusuke Hattori, Tetsuo Sasaki, Makoto Otsuka
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Gels
Subjects:
konjac glucomannan
solid-state mechanochemical reaction
swelling and disintegration property
Fourier-transform infrared spectral change
polymer matrix tablets
sustained drug release kinetics
Online Access:https://www.mdpi.com/2310-2861/8/3/181

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