Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism
Gut microbial and metabolite alterations are linked to inflammatory bowel diseases pathogenesis. Here the authors identify functional microbiota signatures that correlate with disease activity by comparing patients with Crohn’s disease undergoing autologous hematopoietic stem cell transplantation wh...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17956-1 |
| _version_ | 1830288748307283968 |
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| author | Amira Metwaly Andreas Dunkel Nadine Waldschmitt Abilash Chakravarthy Durai Raj Ilias Lagkouvardos Ana Maria Corraliza Aida Mayorgas Margarita Martinez-Medina Sinah Reiter Michael Schloter Thomas Hofmann Matthieu Allez Julian Panes Azucena Salas Dirk Haller |
| author_facet | Amira Metwaly Andreas Dunkel Nadine Waldschmitt Abilash Chakravarthy Durai Raj Ilias Lagkouvardos Ana Maria Corraliza Aida Mayorgas Margarita Martinez-Medina Sinah Reiter Michael Schloter Thomas Hofmann Matthieu Allez Julian Panes Azucena Salas Dirk Haller |
| author_sort | Amira Metwaly |
| collection | DOAJ |
| description | Gut microbial and metabolite alterations are linked to inflammatory bowel diseases pathogenesis. Here the authors identify functional microbiota signatures that correlate with disease activity by comparing patients with Crohn’s disease undergoing autologous hematopoietic stem cell transplantation who either did not respond to therapy, experienced relapse after remission or maintained remission, and show that these microbial signatures recapitulate disease activity when transferred to mice. |
| first_indexed | 2024-12-19T04:40:30Z |
| format | Article |
| id | doaj.art-80a8a0456f1b494a8e06f154f92dc470 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:40:30Z |
| publishDate | 2020-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-80a8a0456f1b494a8e06f154f92dc4702022-12-21T20:35:37ZengNature PortfolioNature Communications2041-17232020-08-0111111510.1038/s41467-020-17956-1Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolismAmira Metwaly0Andreas Dunkel1Nadine Waldschmitt2Abilash Chakravarthy Durai Raj3Ilias Lagkouvardos4Ana Maria Corraliza5Aida Mayorgas6Margarita Martinez-Medina7Sinah Reiter8Michael Schloter9Thomas Hofmann10Matthieu Allez11Julian Panes12Azucena Salas13Dirk Haller14Chair of Nutrition and Immunology, Technical University of MunichLeibniz-Institute for Food Systems Biology, Technical University of MunichChair of Nutrition and Immunology, Technical University of MunichHelmholtz Zentrum München, German Research Center for Environmental Health, Research Unit Comparative Microbiome AnalysisZIEL Institute for Food and Health, Technical University of MunichInflammatory Bowel Disease Unit, Hospital Clínic de Barcelona, IDIBAPS, CIBERehdInflammatory Bowel Disease Unit, Hospital Clínic de Barcelona, IDIBAPS, CIBERehdLaboratory of Molecular Microbiology, Department of Biology, Universitat de GironaChair of Food Chemistry and Molecular Sensory Science, Technical University of MunichHelmholtz Zentrum München, German Research Center for Environmental Health, Research Unit Comparative Microbiome AnalysisChair of Food Chemistry and Molecular Sensory Science, Technical University of MunichAPHP, Hôpital Saint Louis, Department of Gastroenterology, INSERM UMRS 1160, Paris Diderot, Sorbonne Paris-Cité UniversityInflammatory Bowel Disease Unit, Hospital Clínic de Barcelona, IDIBAPS, CIBERehdInflammatory Bowel Disease Unit, Hospital Clínic de Barcelona, IDIBAPS, CIBERehdChair of Nutrition and Immunology, Technical University of MunichGut microbial and metabolite alterations are linked to inflammatory bowel diseases pathogenesis. Here the authors identify functional microbiota signatures that correlate with disease activity by comparing patients with Crohn’s disease undergoing autologous hematopoietic stem cell transplantation who either did not respond to therapy, experienced relapse after remission or maintained remission, and show that these microbial signatures recapitulate disease activity when transferred to mice.https://doi.org/10.1038/s41467-020-17956-1 |
| spellingShingle | Amira Metwaly Andreas Dunkel Nadine Waldschmitt Abilash Chakravarthy Durai Raj Ilias Lagkouvardos Ana Maria Corraliza Aida Mayorgas Margarita Martinez-Medina Sinah Reiter Michael Schloter Thomas Hofmann Matthieu Allez Julian Panes Azucena Salas Dirk Haller Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism Nature Communications |
| title | Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism |
| title_full | Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism |
| title_fullStr | Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism |
| title_full_unstemmed | Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism |
| title_short | Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism |
| title_sort | integrated microbiota and metabolite profiles link crohn s disease to sulfur metabolism |
| url | https://doi.org/10.1038/s41467-020-17956-1 |
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