Body composition, metabolic characteristics, and insulin resistance in obese and nonobese women with polycystic ovary syndrome
Objectives: The objective was to compare body composition, metabolic characteristics, and insulin resistance between obese (body mass index [BMI] ≥25 kg/m2) polycystic ovary syndrome (PCOS) and nonobese PCOS (BMI <25 kg/m2) women and their age- and BMI-matched controls. Materials and Methods: A t...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2019-01-01
|
| Series: | Journal of Human Reproductive Sciences |
| Subjects: | |
| Online Access: | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2019;volume=12;issue=2;spage=78;epage=84;aulast=Satyaraddi |
| _version_ | 1819029125985206272 |
|---|---|
| author | Anil Satyaraddi Kripa Elizabeth Cherian Nitin Kapoor Aleyamma Thaiparambil Kunjummen Mohan S Kamath Nihal Thomas Thomas V Paul |
| author_facet | Anil Satyaraddi Kripa Elizabeth Cherian Nitin Kapoor Aleyamma Thaiparambil Kunjummen Mohan S Kamath Nihal Thomas Thomas V Paul |
| author_sort | Anil Satyaraddi |
| collection | DOAJ |
| description | Objectives: The objective was to compare body composition, metabolic characteristics, and insulin resistance between obese (body mass index [BMI] ≥25 kg/m2) polycystic ovary syndrome (PCOS) and nonobese PCOS (BMI <25 kg/m2) women and their age- and BMI-matched controls. Materials and Methods: A total of 81 PCOS women (Rotterdam criteria) (obese – 42; nonobese – 39) and 86 controls (obese – 42; nonobese –44) were recruited in this cross-sectional study. All women underwent a detailed assessment of clinical, anthropometric, and metabolic parameters, insulin resistance indices, and body composition measurements with visceral adipose tissue assessment (VAT) (dual-energy X-ray absorptiometry scan). Results: Of PCOS women, 27% (80% – obese PCOS; 20% – nonobese PCOS) were diagnosed with metabolic syndrome (International Diabetes Federation criteria), 35% of PCOS women (46% – obese PCOS; 54% – nonobese PCOS) had impaired glucose tolerance, and 7% of PCOS women (2/3rd – obese PCOS; 1/3rd – nonobese PCOS) had diabetes mellitus. Insulin resistance was seen in about 80% in obese PCOS women and 20% in nonobese PCOS women based on various insulin resistance indices such as fasting insulin (≥12.2 μU/ml), Homeostasis Model Assessment-Insulin Resistance (≥2.5), and Quantitative Insulin Sensitivity Check Index (<0.33). Total body fat, estimated (Est.) VAT, and corrected Est. VAT (corrected for body weight) were significantly increased (P = 0.0001) in both obese and nonobese PCOS women when compared to those of their age- and BMI-matched controls. However, corrected Est. VAT (corrected for body weight) was not significantly different between obese and nonobese PCOS women. Conclusion: Both obese and nonobese PCOS women when compared with their age- and BMI-matched controls were metabolically worse and had more visceral adiposity. Nonobese PCOS poses similar risk as that of obese PCOS in having similar amount of VAT (corrected for body weight). |
| first_indexed | 2024-12-21T06:09:18Z |
| format | Article |
| id | doaj.art-80a8c1116f5f4baa80dbaf71d506183b |
| institution | Directory Open Access Journal |
| issn | 0974-1208 1998-4766 |
| language | English |
| last_indexed | 2024-12-21T06:09:18Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Human Reproductive Sciences |
| spelling | doaj.art-80a8c1116f5f4baa80dbaf71d506183b2022-12-21T19:13:34ZengWolters Kluwer Medknow PublicationsJournal of Human Reproductive Sciences0974-12081998-47662019-01-01122788410.4103/jhrs.JHRS_2_19Body composition, metabolic characteristics, and insulin resistance in obese and nonobese women with polycystic ovary syndromeAnil SatyaraddiKripa Elizabeth CherianNitin KapoorAleyamma Thaiparambil KunjummenMohan S KamathNihal ThomasThomas V PaulObjectives: The objective was to compare body composition, metabolic characteristics, and insulin resistance between obese (body mass index [BMI] ≥25 kg/m2) polycystic ovary syndrome (PCOS) and nonobese PCOS (BMI <25 kg/m2) women and their age- and BMI-matched controls. Materials and Methods: A total of 81 PCOS women (Rotterdam criteria) (obese – 42; nonobese – 39) and 86 controls (obese – 42; nonobese –44) were recruited in this cross-sectional study. All women underwent a detailed assessment of clinical, anthropometric, and metabolic parameters, insulin resistance indices, and body composition measurements with visceral adipose tissue assessment (VAT) (dual-energy X-ray absorptiometry scan). Results: Of PCOS women, 27% (80% – obese PCOS; 20% – nonobese PCOS) were diagnosed with metabolic syndrome (International Diabetes Federation criteria), 35% of PCOS women (46% – obese PCOS; 54% – nonobese PCOS) had impaired glucose tolerance, and 7% of PCOS women (2/3rd – obese PCOS; 1/3rd – nonobese PCOS) had diabetes mellitus. Insulin resistance was seen in about 80% in obese PCOS women and 20% in nonobese PCOS women based on various insulin resistance indices such as fasting insulin (≥12.2 μU/ml), Homeostasis Model Assessment-Insulin Resistance (≥2.5), and Quantitative Insulin Sensitivity Check Index (<0.33). Total body fat, estimated (Est.) VAT, and corrected Est. VAT (corrected for body weight) were significantly increased (P = 0.0001) in both obese and nonobese PCOS women when compared to those of their age- and BMI-matched controls. However, corrected Est. VAT (corrected for body weight) was not significantly different between obese and nonobese PCOS women. Conclusion: Both obese and nonobese PCOS women when compared with their age- and BMI-matched controls were metabolically worse and had more visceral adiposity. Nonobese PCOS poses similar risk as that of obese PCOS in having similar amount of VAT (corrected for body weight).http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2019;volume=12;issue=2;spage=78;epage=84;aulast=SatyaraddiInsulin resistancenonobese polycystic ovary syndromeobese polycystic ovary syndromepolycystic ovary syndromevisceral adipose tissue |
| spellingShingle | Anil Satyaraddi Kripa Elizabeth Cherian Nitin Kapoor Aleyamma Thaiparambil Kunjummen Mohan S Kamath Nihal Thomas Thomas V Paul Body composition, metabolic characteristics, and insulin resistance in obese and nonobese women with polycystic ovary syndrome Journal of Human Reproductive Sciences Insulin resistance nonobese polycystic ovary syndrome obese polycystic ovary syndrome polycystic ovary syndrome visceral adipose tissue |
| title | Body composition, metabolic characteristics, and insulin resistance in obese and nonobese women with polycystic ovary syndrome |
| title_full | Body composition, metabolic characteristics, and insulin resistance in obese and nonobese women with polycystic ovary syndrome |
| title_fullStr | Body composition, metabolic characteristics, and insulin resistance in obese and nonobese women with polycystic ovary syndrome |
| title_full_unstemmed | Body composition, metabolic characteristics, and insulin resistance in obese and nonobese women with polycystic ovary syndrome |
| title_short | Body composition, metabolic characteristics, and insulin resistance in obese and nonobese women with polycystic ovary syndrome |
| title_sort | body composition metabolic characteristics and insulin resistance in obese and nonobese women with polycystic ovary syndrome |
| topic | Insulin resistance nonobese polycystic ovary syndrome obese polycystic ovary syndrome polycystic ovary syndrome visceral adipose tissue |
| url | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2019;volume=12;issue=2;spage=78;epage=84;aulast=Satyaraddi |
| work_keys_str_mv | AT anilsatyaraddi bodycompositionmetaboliccharacteristicsandinsulinresistanceinobeseandnonobesewomenwithpolycysticovarysyndrome AT kripaelizabethcherian bodycompositionmetaboliccharacteristicsandinsulinresistanceinobeseandnonobesewomenwithpolycysticovarysyndrome AT nitinkapoor bodycompositionmetaboliccharacteristicsandinsulinresistanceinobeseandnonobesewomenwithpolycysticovarysyndrome AT aleyammathaiparambilkunjummen bodycompositionmetaboliccharacteristicsandinsulinresistanceinobeseandnonobesewomenwithpolycysticovarysyndrome AT mohanskamath bodycompositionmetaboliccharacteristicsandinsulinresistanceinobeseandnonobesewomenwithpolycysticovarysyndrome AT nihalthomas bodycompositionmetaboliccharacteristicsandinsulinresistanceinobeseandnonobesewomenwithpolycysticovarysyndrome AT thomasvpaul bodycompositionmetaboliccharacteristicsandinsulinresistanceinobeseandnonobesewomenwithpolycysticovarysyndrome |