Molecular mechanisms for pharmacological effects of drugs based on Cimicifuga racemosa extracts
An estrogen-like activity is considered to be the main mechanism of action for Cimicifuga extract. At the same time, results of modern studies of molecular composition together with modern fundamental data indicate such critical mechanisms of action as activation of serotoninergic and GABA-ergic way...
| Main Authors: | , , , , |
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| 格式: | 文件 |
| 语言: | Russian |
| 出版: |
IP Berlin A.V.
2018-01-01
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| 丛编: | Гинекология |
| 主题: | |
| 在线阅读: | http://gynecology.orscience.ru/en/archive/2018/vol-20-1-2018/8_2834/?element |
| _version_ | 1830281948571893760 |
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| author | O.A.Gromova I.Yu.Torshin N.K.Tetruashvili L.E.Fedotova N.P.Lapochkina |
| author_facet | O.A.Gromova I.Yu.Torshin N.K.Tetruashvili L.E.Fedotova N.P.Lapochkina |
| author_sort | O.A.Gromova |
| collection | DOAJ |
| description | An estrogen-like activity is considered to be the main mechanism of action for Cimicifuga extract. At the same time, results of modern studies of molecular composition together with modern fundamental data indicate such critical mechanisms of action as activation of serotoninergic and GABA-ergic ways of neurotransmission, as well as anti-inflammatory and antidiabetic effects. The use of drugs based on C. racemosa extracts is perspective for accompanying replacement hormonal therapy with estrogens due to antineoplastic and osteoprotective effects of standardized C. racemosa extracts. |
| first_indexed | 2024-12-19T02:28:36Z |
| format | Article |
| id | doaj.art-80a94e5aee4d4c66a47951d10cdda7a1 |
| institution | Directory Open Access Journal |
| issn | 2079-5696 2079-5831 |
| language | Russian |
| last_indexed | 2024-12-19T02:28:36Z |
| publishDate | 2018-01-01 |
| publisher | IP Berlin A.V. |
| record_format | Article |
| series | Гинекология |
| spelling | doaj.art-80a94e5aee4d4c66a47951d10cdda7a12022-12-21T20:39:48ZrusIP Berlin A.V.Гинекология2079-56962079-58312018-01-01201394610.26442/2079-5696_20.1.39-46Molecular mechanisms for pharmacological effects of drugs based on Cimicifuga racemosa extractsO.A.Gromova0I.Yu.Torshin1N.K.Tetruashvili2L.E.Fedotova3N.P.Lapochkina41Federal Research Centre "Information and Management" of the Russian Academy of Sciences. 119333, Russian Federation, Moscow, ul. Vavilova, d. 44, кorp. 2; 2Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation. 153462, Russian Federation, Ivanovo, pr. Sheremetevskii, d. 8Federal Research Centre "Information and Management" of the Russian Academy of Sciences. 119333, Russian Federation, Moscow, ul. Vavilova, d. 44, кorp. 2V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation. 153462, Russian Federation, Ivanovo, pr. Sheremetevskii, d. 8Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation. 153462, Russian Federation, Ivanovo, pr. Sheremetevskii, d. 8An estrogen-like activity is considered to be the main mechanism of action for Cimicifuga extract. At the same time, results of modern studies of molecular composition together with modern fundamental data indicate such critical mechanisms of action as activation of serotoninergic and GABA-ergic ways of neurotransmission, as well as anti-inflammatory and antidiabetic effects. The use of drugs based on C. racemosa extracts is perspective for accompanying replacement hormonal therapy with estrogens due to antineoplastic and osteoprotective effects of standardized C. racemosa extracts.http://gynecology.orscience.ru/en/archive/2018/vol-20-1-2018/8_2834/?elementclimacteriumcimicifugasepiasanguinariaKlimaktoplan N |
| spellingShingle | O.A.Gromova I.Yu.Torshin N.K.Tetruashvili L.E.Fedotova N.P.Lapochkina Molecular mechanisms for pharmacological effects of drugs based on Cimicifuga racemosa extracts Гинекология climacterium cimicifuga sepia sanguinaria Klimaktoplan N |
| title | Molecular mechanisms for pharmacological effects of drugs based on Cimicifuga racemosa extracts |
| title_full | Molecular mechanisms for pharmacological effects of drugs based on Cimicifuga racemosa extracts |
| title_fullStr | Molecular mechanisms for pharmacological effects of drugs based on Cimicifuga racemosa extracts |
| title_full_unstemmed | Molecular mechanisms for pharmacological effects of drugs based on Cimicifuga racemosa extracts |
| title_short | Molecular mechanisms for pharmacological effects of drugs based on Cimicifuga racemosa extracts |
| title_sort | molecular mechanisms for pharmacological effects of drugs based on cimicifuga racemosa extracts |
| topic | climacterium cimicifuga sepia sanguinaria Klimaktoplan N |
| url | http://gynecology.orscience.ru/en/archive/2018/vol-20-1-2018/8_2834/?element |
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