TIPE2 knockdown exacerbates isoflurane-induced postoperative cognitive impairment in mice by inducing activation of STAT3 and NF-κB signaling pathways
Anesthetic exposure causes learning and memory impairment, the mechanisms of which remain unknown. It has been reported that tumor necrosis factor-α-inducer protein 8-like 2 (TIPE2) is a newly discovered immune negative regulator that is essential for maintaining immune homeostasis. This study aimed...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2023-04-01
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| Series: | Translational Neuroscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/tnsci-2022-0282 |
| _version_ | 1797832430208417792 |
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| author | Jian Rui He Xin |
| author_facet | Jian Rui He Xin |
| author_sort | Jian Rui |
| collection | DOAJ |
| description | Anesthetic exposure causes learning and memory impairment, the mechanisms of which remain unknown. It has been reported that tumor necrosis factor-α-inducer protein 8-like 2 (TIPE2) is a newly discovered immune negative regulator that is essential for maintaining immune homeostasis. This study aimed to examine the role of TIPE2 in isoflurane-induced postoperative cognitive decline (POCD). |
| first_indexed | 2024-04-09T14:07:39Z |
| format | Article |
| id | doaj.art-80ab3a9826c64c718d2a40e69ad1962b |
| institution | Directory Open Access Journal |
| issn | 2081-6936 |
| language | English |
| last_indexed | 2024-04-09T14:07:39Z |
| publishDate | 2023-04-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Translational Neuroscience |
| spelling | doaj.art-80ab3a9826c64c718d2a40e69ad1962b2023-05-06T15:58:55ZengDe GruyterTranslational Neuroscience2081-69362023-04-011418859310.1515/tnsci-2022-0282TIPE2 knockdown exacerbates isoflurane-induced postoperative cognitive impairment in mice by inducing activation of STAT3 and NF-κB signaling pathwaysJian Rui0He Xin1Department of Rehabilitation Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, ChinaDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, ChinaAnesthetic exposure causes learning and memory impairment, the mechanisms of which remain unknown. It has been reported that tumor necrosis factor-α-inducer protein 8-like 2 (TIPE2) is a newly discovered immune negative regulator that is essential for maintaining immune homeostasis. This study aimed to examine the role of TIPE2 in isoflurane-induced postoperative cognitive decline (POCD).https://doi.org/10.1515/tnsci-2022-0282pocdtipe2stat3nf-κbhippocampusmicroglia |
| spellingShingle | Jian Rui He Xin TIPE2 knockdown exacerbates isoflurane-induced postoperative cognitive impairment in mice by inducing activation of STAT3 and NF-κB signaling pathways Translational Neuroscience pocd tipe2 stat3 nf-κb hippocampus microglia |
| title | TIPE2 knockdown exacerbates isoflurane-induced postoperative cognitive impairment in mice by inducing activation of STAT3 and NF-κB signaling pathways |
| title_full | TIPE2 knockdown exacerbates isoflurane-induced postoperative cognitive impairment in mice by inducing activation of STAT3 and NF-κB signaling pathways |
| title_fullStr | TIPE2 knockdown exacerbates isoflurane-induced postoperative cognitive impairment in mice by inducing activation of STAT3 and NF-κB signaling pathways |
| title_full_unstemmed | TIPE2 knockdown exacerbates isoflurane-induced postoperative cognitive impairment in mice by inducing activation of STAT3 and NF-κB signaling pathways |
| title_short | TIPE2 knockdown exacerbates isoflurane-induced postoperative cognitive impairment in mice by inducing activation of STAT3 and NF-κB signaling pathways |
| title_sort | tipe2 knockdown exacerbates isoflurane induced postoperative cognitive impairment in mice by inducing activation of stat3 and nf κb signaling pathways |
| topic | pocd tipe2 stat3 nf-κb hippocampus microglia |
| url | https://doi.org/10.1515/tnsci-2022-0282 |
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