Prevalence of Antibiotic Residues in Milk Consumed in Iran: A Systematic Review and Meta-Analysis
Background: Improper use of antibiotics and not paying attention to withdrawal time causes antibiotics to enter the milk, which can cause allergies in humans and cause antibiotic-resistant pathogenic bacteria in the long run, so quality and hygienic milk control is essential.Methods: This study aime...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2023-10-01
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| Series: | Journal of Health Sciences and Surveillance System |
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| Online Access: | https://jhsss.sums.ac.ir/article_49615_3bc0e8541d502a351c2a3aeaa1c13ad2.pdf |
| _version_ | 1797635820173131776 |
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| author | Hassan Jolaei Mostafa Abdollahi Maryam Safarirad Enayat Berizi Mohammad Hashem Yousefi Seyyed Mohammad Ali Noori |
| author_facet | Hassan Jolaei Mostafa Abdollahi Maryam Safarirad Enayat Berizi Mohammad Hashem Yousefi Seyyed Mohammad Ali Noori |
| author_sort | Hassan Jolaei |
| collection | DOAJ |
| description | Background: Improper use of antibiotics and not paying attention to withdrawal time causes antibiotics to enter the milk, which can cause allergies in humans and cause antibiotic-resistant pathogenic bacteria in the long run, so quality and hygienic milk control is essential.Methods: This study aimed to investigate the prevalence of antibiotic residues in milk as a systematic review and metaanalysis from 2004 to 2021 for 15 years in Iran. The data were collected from four international search databases, including PubMed, Scopus, Science Direct, and Google Scholar, and four Iranian databases, including SID, MagIran, Civilica, and IranDoc.Results: After reviews of 314 studies, 38 were finally selected, and the information was recorded and analyzed in Stata software. The results of this study show that the residual prevalence of antibiotics in milk using the screening method was 28% (CI: 0.34-0.22). The residual rates of antibiotics using enzymelinked immunosorbent assay (ELISA) and high-pressure liquid chromatography (HPLC) methods were 43% (CI: 0.26-0.59) and 27% (CI: 0.05-0.49), respectively.Conclusion: The data obtained from the meta-analysis show that despite various reports of a quantitative amount of antibiotic residue in milk, the average amount in the ELISA method was 16.98 ppm. Although the prevalence of antibiotics in Iran is relatively high, a quantitative amount is optimal. Also, since the use of antibiotics in livestock is almost inevitable, proper withdrawal time of antibiotics can play an important role in preventing the release of antibiotic residues in milk. |
| first_indexed | 2024-03-11T12:26:48Z |
| format | Article |
| id | doaj.art-80afeeb7fe6f46329c87e5cc71e99f00 |
| institution | Directory Open Access Journal |
| issn | 2345-2218 2345-3893 |
| language | English |
| last_indexed | 2024-03-11T12:26:48Z |
| publishDate | 2023-10-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Journal of Health Sciences and Surveillance System |
| spelling | doaj.art-80afeeb7fe6f46329c87e5cc71e99f002023-11-06T08:44:46ZengShiraz University of Medical SciencesJournal of Health Sciences and Surveillance System2345-22182345-38932023-10-0111469670310.30476/jhsss.2022.94778.155549615Prevalence of Antibiotic Residues in Milk Consumed in Iran: A Systematic Review and Meta-AnalysisHassan Jolaei0Mostafa Abdollahi1Maryam Safarirad2Enayat Berizi3Mohammad Hashem Yousefi4Seyyed Mohammad Ali Noori5Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, IranHealth Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Food Hygiene and Quality Control, Faculty of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Food Hygiene and Quality Control, Faculty of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Food Hygiene and Public Health, School of Veterinary Medicine, Shiraz University, Shiraz, IranDepartment of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranBackground: Improper use of antibiotics and not paying attention to withdrawal time causes antibiotics to enter the milk, which can cause allergies in humans and cause antibiotic-resistant pathogenic bacteria in the long run, so quality and hygienic milk control is essential.Methods: This study aimed to investigate the prevalence of antibiotic residues in milk as a systematic review and metaanalysis from 2004 to 2021 for 15 years in Iran. The data were collected from four international search databases, including PubMed, Scopus, Science Direct, and Google Scholar, and four Iranian databases, including SID, MagIran, Civilica, and IranDoc.Results: After reviews of 314 studies, 38 were finally selected, and the information was recorded and analyzed in Stata software. The results of this study show that the residual prevalence of antibiotics in milk using the screening method was 28% (CI: 0.34-0.22). The residual rates of antibiotics using enzymelinked immunosorbent assay (ELISA) and high-pressure liquid chromatography (HPLC) methods were 43% (CI: 0.26-0.59) and 27% (CI: 0.05-0.49), respectively.Conclusion: The data obtained from the meta-analysis show that despite various reports of a quantitative amount of antibiotic residue in milk, the average amount in the ELISA method was 16.98 ppm. Although the prevalence of antibiotics in Iran is relatively high, a quantitative amount is optimal. Also, since the use of antibiotics in livestock is almost inevitable, proper withdrawal time of antibiotics can play an important role in preventing the release of antibiotic residues in milk.https://jhsss.sums.ac.ir/article_49615_3bc0e8541d502a351c2a3aeaa1c13ad2.pdfanti-bacterial agentsiranmeta-analysismilkprevalence |
| spellingShingle | Hassan Jolaei Mostafa Abdollahi Maryam Safarirad Enayat Berizi Mohammad Hashem Yousefi Seyyed Mohammad Ali Noori Prevalence of Antibiotic Residues in Milk Consumed in Iran: A Systematic Review and Meta-Analysis Journal of Health Sciences and Surveillance System anti-bacterial agents iran meta-analysis milk prevalence |
| title | Prevalence of Antibiotic Residues in Milk Consumed in Iran: A Systematic Review and Meta-Analysis |
| title_full | Prevalence of Antibiotic Residues in Milk Consumed in Iran: A Systematic Review and Meta-Analysis |
| title_fullStr | Prevalence of Antibiotic Residues in Milk Consumed in Iran: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Prevalence of Antibiotic Residues in Milk Consumed in Iran: A Systematic Review and Meta-Analysis |
| title_short | Prevalence of Antibiotic Residues in Milk Consumed in Iran: A Systematic Review and Meta-Analysis |
| title_sort | prevalence of antibiotic residues in milk consumed in iran a systematic review and meta analysis |
| topic | anti-bacterial agents iran meta-analysis milk prevalence |
| url | https://jhsss.sums.ac.ir/article_49615_3bc0e8541d502a351c2a3aeaa1c13ad2.pdf |
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